91543-47-4Relevant academic research and scientific papers
Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones
Nozawa-Kumada, Kanako,Matsuzawa, Yuta,Ono, Kanako,Shigeno, Masanori,Kondo, Yoshinori
supporting information, p. 8604 - 8607 (2021/09/02)
A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp3)-H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp3)-H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp3)-H bonds and shows excellent functional group tolerance. This journal is
Nickel-catalyzed direct addition of diorganozinc reagents to phthalimides: Selective formation of gamma-hydroxylactams
Dennis, Joseph M.,Calyore, Catherine M.,Sjoholm, Jessica S.,Lutz, J. Patrick,Gair, Joseph J.,Johnson, Jeffrey B.
, p. 2567 - 2570 (2013/12/04)
The nickel-catalyzed addition of diorganozinc reagents to phthalimides proceeds with excellent selectivity to provide 3-substituted-3- hydroxyisoindolin-1-one products. These 3-hydroxy-γ-lactams are produced cleanly in high yield with numerous examples of imide substitution and a broad range of diorganozinc reagents that are prepared and utilized without purification. Georg Thieme Verlag Stuttgart · New York.
