91546-70-2Relevant academic research and scientific papers
Synthesis and cytotoxicity evaluation of some novel chromone annulated phosphorus heterocycles
Ali, Tarik E.,Ibrahim, Magdy A.,El-Edfawy, Somaya M.
, p. 819 - 826 (2017/07/22)
Novel chromono[2,3-e][1,2,4,3]triazaphosphepines 3?7, chromono[2,3-d][1,3,2]diazaphosphinine 8, chro-monyl α-hydrazinophosphonic acid 10, chromono[3,2-d][1,2]azaphosphole 11 and diethyl N-chromony-lphosphonoacetamide 12 were synthesized from treatment of 2-amino-3-[(2-phenylhydrazinylidene)methyl]chromone (2) with some phosphorus reagents such as phosphorus halides, phosphorus sulfides, and phosphonic acid and its diesters, in dry dioxane. The cytotoxic effects of the synthesized compounds were evaluated in vitro in relation to hepatocellular Hep-G2, breast MCF-7 and colon HCT-116 human cancer cell lines, using a crystal violet viability assay. Compounds 6, 7, 8, and 10 had significant cytotoxic effects against the three cancer cell lines. Their IC50 values ranged between 1.56 and 12.4?μg/mL in comparison to doxorubicin (IC50 = 0.426-0.469?μg/mL).
On the reaction of 3-cyanochromones with phenyl- and methylhydrazines: Structural revision and a simple synthesis of chromeno[4,3-c]pyrazol-4-ones
Sosnovskikh, Vyacheslav Ya,Moshkin, Vladimir S.,Kodess, Mikhail I.
experimental part, p. 629 - 633 (2010/07/18)
(Chemical Equation Presented) Reactions of 3-cyanochromones with phenylhydrazine gave the corresponding 5-amino-4-salicyloyl-1-phenylpyrazoles, 2-aminochromone-3-carbaldehyde N-phenylhydrazones, and 1-phenylchromeno[4,3-c] pyrazol-4(1H)-one, depending on
Heterocyclic Systems: Part XIII - Reactions of 3-N,N-Dimethylhydrazonomethyl-, Oximomethyl- and Cyano-chromones with Nucleophiles Containing Nitrogen
Ghosh, Chandra Kanta,Tewari, Nimai,Bandyopadhyay, Chandrakanta
, p. 1200 - 1204 (2007/10/02)
Reactions of the title chromones (3, 9, 10) with nitrogen containing nucleophiles (5-7) have been studied.When treated with phenylhydrazine, the hydrazone (9) produces the same pyrazole 17 (R'=Ph) as obtained by reacting chromone-3-carboxaldehyde (8) with
