91560-17-7Relevant academic research and scientific papers
Convenient synthesis of 2-substituted 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones
Kókai, Eszter,Nagy, József,Tóth, Tünde,Kupai, József,Huszthy, Péter,Simig, Gyula,Volk, Balázs
, p. 767 - 773 (2016)
A new synthetic route was elaborated at our laboratory providing a convenient access to 5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-ones (diazaoxindoles), a compound family of biological relevance. Treatment of the easily available ethyl 2-(4-chloropyrimidin-5-yl)acetate derivatives with ammonia afforded the corresponding 2-(4-aminopyrimidin-5-yl)acetamides, which were finally cyclized to the target compounds.
