91564-56-6Relevant academic research and scientific papers
Synthesis and spectroscopic studies of some hydrogenated thiazolo[2,3-a]isoquinolines
Rozwadowska, Maria D,Sulima, Agnieszka
, p. 3499 - 3506 (2001)
Dihydro-5H-thiazolo[2,3-a]isoquinolinones (1-6) and tetrahydro-5H-thiazolo[2,3a]isoquinolines (7-12) have been prepared from 3,4-dihydroisoquinoline derivatives under the action of α-mercapto alkanoic acids or ethylene sulfide, respectively. In the synthe
Application of the ortho-Lithiation-Cyclization Strategy to N-Benzyl- and N-Phenethylamine Derivatives
Lete, Esther,Collado, M. Isabel,Sotomayor, Nuria,Vicente, Teresa,Villa, Maria-Jesus
, p. 1751 - 1758 (2007/10/03)
The ortho-lithiation-cyclization of iodinated N,N-diacylphenethylamines provides a convenient method for the preparation of 2-(2-acetoamidoethyl)acetophenones and 2-(2-benzamidoethyl)benzophenones, which could be easily transformed into dihydroisoquinolines.By contrast, the N-ethylamino, N-acetylamino, and N-trimethylsilylamino moieties studied as ortho-directing groups provide poor assistance to the metalation of N-benzyl- and N-phenyethylamines and the corresponding isoindolone or isoquinolone derivatives are obtained in low yields.
