91569-20-9Relevant academic research and scientific papers
Aniline pyrimidines, its preparation method and medical use (by machine translation)
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Paragraph 0663; 0664; 0665; 0666, (2018/03/01)
The invention relates to: an aniline pyrimidine compound represented as the formula (I), a medicinal salt thereof, a prodrug thereof, and a hydrate or solvate thereof and also relates to: the preparation method of the compound, a medicine composition comp
Discovery of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors
Lv, Yongcong,Li, Mengyuan,Cao, Sufen,Tong, Linjiang,Peng, Ting,Wei, Lixin,Xie, Hua,Ding, Jian,Duan, Wenhu
supporting information, p. 1375 - 1380 (2015/07/15)
Vascular endothelial growth factor receptor-2 (VEGFR-2) plays an important role in tumor angiogenesis, and inhibition of the VEGFR-2 signaling pathway has emerged as an attractive strategy for the treatment of cancer. Herein, we describe the design, synthesis, and biological evaluation of anilinopyrimidine-based naphthamide derivatives as potent VEGFR-2 inhibitors. Among the new derivatives, compound 3k exhibited high VEGFR-2 inhibitory potency in both enzymatic and VEGF-induced HUVEC cellular proliferation assays (IC50 = 0.5 and 9.8 nM, respectively). Kinase selectivity profiling revealed that 3k was a highly selective VEGFR-2 inhibitor. Moreover, 3k effectively inhibited angiogenesis in HUVEC tube formation assay.
Naphthamides as novel and potent vascular endothelial growth factor receptor tyrosine kinase inhibitors: Design, synthesis, and evaluation
Harmange, Jean-Christophe,Weiss, Matthew M.,Germain, Julie,Polverino, Anthony J.,Borg, George,Bready, James,Chen, Danlin,Choquette, Deborah,Coxon, Angela,DeMelfi, Tom,DiPietro, Lucian,Doerr, Nicholas,Estrada, Juan,Flynn, Julie,Graceffa, Russell F.,Harriman, Shawn P.,Kaufman, Stephen,La, Daniel S.,Long, Alexander,Martin, Matthew W.,Neervannan, Sesha,Patel, Vinod F.,Potashman, Michele,Regal, Kelly,Roveto, Phillip M.,Schrag, Michael L.,Starnes, Charlie,Tasker, Andrew,Teffera, Yohannes,Wang, Ling,White, Ryan D.,Whittington, Douglas A.,Zanon, Roger
, p. 1649 - 1667 (2008/09/20)
A series of naphthyl-based compounds were synthesized as potential inhibitors of vascular endothelial growth factor (VEGF) receptors. Investigations of structure-activity relationships led to the identification of a series of naphthamides that are potent inhibitors of the VEGF receptor tyrosine kinase family. Numerous analogues demonstrated low nanomolar inhibition of VEGF-dependent human umbilical vein endothelial cell (HUVEC) proliferation, and of these several compounds possessed favorable pharmacokinetic (PK) profiles. In particular, compound 48 demonstrated significant antitumor efficacy against established HT29 human colon adenocarcinoma xenografts implanted in athymic mice. A full account of the preparation, structure-activity relationships, pharmacokinetic properties, and pharmacology of analogues within this series is presented.
