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2437-17-4

6-Hydroxy-1-naphthoic acid is a chemical intermediate used in the synthesis of simplified aplysiatoxin analogs, such as compound **2**, which incorporates a naphthalene ring to enhance CH/π interactions with the PKC δ-C1B domain. While this derivative demonstrated improved anti-proliferative activity against cancer cells, its binding affinity to PKC did not surpass that of other analogs, indicating the need for further structural refinement to optimize therapeutic efficacy.

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  • 2437-17-4 Structure

  • Basic information

    1. Product Name: 6-Hydroxy-1-naphthoic acid
    2. Synonyms: 6-HYDROXY-1-NAPHTHOIC ACID;2-NAPHTHOL-5-CARBOXYLIC ACID;OHNA;6-Hydroxynaphthoic acid;6-hydroxynaphthalene-1-carboxylic acid;6-HYDROXY-1-NAPHTHOIC ACID 95+%;6-Hydroxy-1-naphthalenecarboxylic acid
    3. CAS NO:2437-17-4
    4. Molecular Formula: C11H8O3
    5. Molecular Weight: 188.18
    6. EINECS: 407-390-5
    7. Product Categories: Naphthalene derivatives
    8. Mol File: 2437-17-4.mol

  • Chemical Properties

    1. Melting Point: 210°C
    2. Boiling Point: 445.7°C at 760 mmHg
    3. Flash Point: 237.5°C
    4. Appearance: White to light yellow crystal powder
    5. Density: 1.399g/cm3
    6. Vapor Pressure: 1E-08mmHg at 25°C
    7. Refractive Index: 1.716
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: soluble in Methanol
    10. PKA: 3.76±0.10(Predicted)
    11. CAS DataBase Reference: 6-Hydroxy-1-naphthoic acid(CAS DataBase Reference)
    12. NIST Chemistry Reference: 6-Hydroxy-1-naphthoic acid(2437-17-4)
    13. EPA Substance Registry System: 6-Hydroxy-1-naphthoic acid(2437-17-4)

  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 36/37/38-51-36-22
    3. Safety Statements: 26-36/37/39
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 2437-17-4(Hazardous Substances Data)

2437-17-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 2437-17-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,4,3 and 7 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 2437-17:
(6*2)+(5*4)+(4*3)+(3*7)+(2*1)+(1*7)=74
74 % 10 = 4
So 2437-17-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H8O3/c12-8-4-5-9-7(6-8)2-1-3-10(9)11(13)14/h1-6,12H,(H,13,14)

2437-17-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 6-hydroxynaphthalene-1-carboxylic acid

1.2 Other means of identification

Product number -
Other names 6-Hydroxy-1-naphthoic acid

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2437-17-4 SDS

2437-17-4Relevant articles and documents

Method for preparing 6-hydroxyl-1-naphthoic acid

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Paragraph 0035; 0037; 0038-0039; 0041; 0043; 0045; 0047, (2018/12/13)

The invention discloses a method for preparing 6-hydroxyl-1-naphthoic acid and belongs to the technical field of organic synthesis. The method comprises the steps: subjecting furoic acid and methylphenyl ether, which serve as starting raw materials, to a reaction in the presence of Lewis acid, so as to prepare 6-methoxy-1-naphthoic acid; carrying out removal with the Lewis acid without separationto remove methyl, thereby preparing the high-purity 6-hydroxyl-1-naphthoic acid in a high-yield manner, wherein the purity of 6-hydroxyl-1-naphthoic acid reaches up to 98.0%. The method has the advantages that the source of the raw materials is wide, the process flow is simple and convenient, the corrosiveness to equipment is low, and pilot test proves that the industrial production is facilitated.

The mercury-mediated decarboxylation (Pesci reaction) of naphthoic anhydrides investigated by microwave synthesis

Moseley, Jonathan D.,Gilday, John P.

, p. 4690 - 4697 (2007/10/03)

The mercury-mediated decarboxylation (Pesci reaction) of several substituted naphthoic anhydrides has been investigated by microwave synthesis. A laboratory microwave reactor was found to be ideal for small-scale preparations of this slow reaction, reducing reaction times from typically four days to less than 1 h for the three-step process. The ionic reaction medium rapidly heated to high temperatures under microwave heating and could be efficiently maintained by low microwave power settings. Generation of stoichiometric CO2 was safely contained within the reaction tubes. A simplified reaction procedure has been developed. For substituted naphthoic anhydrides, 1H NMR analysis of the naphthoate ester derivatives indicated no change in the regioisomer ratio compared to previously reported thermal values.

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