915701-02-9Relevant academic research and scientific papers
The discovery of novel indole-2-carboxamides as cannabinoid CB1 receptor antagonists
Cowley, Phillip M.,Baker, James,Barn, David R.,Buchanan, Kirsteen I.,Carlyle, Ian,Clark, John K.,Clarkson, Thomas R.,Deehan, Maureen,Edwards, Darren,Goodwin, Richard R.,Jaap, David,Kiyoi, Yasuko,Mort, Chris,Palin, Ronald,Prosser, Alan,Walker, Glenn,Ward, Nick,Wishart, Grant,Young, Trevor
scheme or table, p. 497 - 501 (2011/02/24)
The discovery and structure-activity relationship of a novel series of indole-2-carboxamide antagonists of the cannabinoid CB1 receptor is disclosed. Compound 26i was found to be a high potency, selective cannabinoid CB1 antagonist.
Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-γ binding agents with potential application to the treatment of osteoporosis
Hopkins, Corey R.,O'Neil, Steven V.,Laufersweiler, Michael C.,Wang, Yili,Pokross, Matthew,Mekel, Marlene,Evdokimov, Artem,Walter, Richard,Kontoyianni, Maria,Petrey, Maria E.,Sabatakos, Georgios,Roesgen, Jeff T.,Richardson, Eloise,Demuth Jr., Thomas P.
, p. 5659 - 5663 (2007/10/03)
The synthesis and structure-activity relationships of a novel series of N-sulfonyl-2-indole carboxamides that bind to peroxisome proliferator-activated receptor gamma (PPAR-γ) are reported. Chemical optimization of the series led to the identification of 4q (IC50 = 50 nM) as a potent binding agent of PPAR-γ. Also reported is preliminary cell based data suggesting the use of these compounds in the treatment of osteoporosis.
