915715-25-2

Upstream product

• 59408-74-1 (S)-2-((tert-butoxy)carbonylamino)-4-(phenylmethoxy)butyric acid 

Downstream Products

• 486460-00-8 (3R)-3-[(1,1-dimethylethoxycarbonyl)amino]-4-(2,4,5-trifluorophenyl)butanoic acid 
• 1048703-14-5 (R)-tert-butyl (4-hydroxy-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate 
• 1380243-39-9 C₂₂H₂₆F₃NO₃ 
• 1380243-25-3 C₁₆H₂₃NO₃ 
• 486460-23-5 (R)-tert-butyl 4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-ylcarbamate 
• 1205542-86-4 ((S)-3-Benzyloxy-1-methoxymethyl-propyl)-carbamic acid tert-butyl ester 
• 944953-01-9 [3-benzyloxy-1(R)-cyanomethyl-propyl]-carbamic acid tert-butyl ester 
• 915715-26-3 (S)-4-benzyloxy-2-N-Boc-1-N'-phtaloyl-butane-1,2-diamine 

Relevant academic research and scientific papers

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.

INTERMEDIATES OF SITAGLIPTIN AND PREPARATION PROCESS THEREOF

Disclosed are intermediates of Sitagliptin, a preparation process thereof, and a process for synthesizing Sitagliptin using these intermediates. Sitagliptin is synthesized by using chiral amino compounds as a raw material, without having to build a chiral center with a chiral asymmetric catalytic hydrogenation, and high-pressure hydrogenation is avoided.