91591-70-7

Usage

Uses

Used in Pharmaceutical Industry:
2,6-Dichloro-4-methylpyridine-3-carboxaldehyde is used as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs and improving existing ones. Its unique structure and properties make it a key component in the creation of medicinal compounds.
Used in Agrochemical Industry:
In the agrochemical sector, 2,6-Dichloro-4-methylpyridine-3-carboxaldehyde is employed as an intermediate in the production of pesticides. Its incorporation aids in the development of effective and targeted pest control solutions, enhancing agricultural productivity and crop protection.
Used in Organic Chemistry as a Reagent:
2,6-Dichloro-4-methylpyridine-3-carboxaldehyde is utilized as a reagent in organic chemistry reactions, facilitating the synthesis of complex organic compounds. Its structure and properties make it an indispensable tool for researchers and chemists in the field of organic chemistry.

Upstream product

• 62774-90-7 2,6-dichloro-4-methyl-nicotinic acid 
• 1086322-08-8 (2,6-dichloro-4-methylpyridin-3-yl)methanol 
• 875-35-4 2,6-dichloro-4-methylnicotinonitrile 

Downstream Products

• 220559-34-2 methyl 4.6-dichloro-3-(diethylamino)furo[3,4-c]pyridine-1-carboxylate 
• 62774-90-7 2,6-dichloro-4-methyl-nicotinic acid 

Relevant academic research and scientific papers

CYCLIC COMPOUNDS AND METHODS OF USING SAME

The present application relates to compounds of Formula (I), as defined herein, and pharmaceutically acceptable salts thereof which are MALT1 inhibitors. The present application also describes pharmaceutical composition comprising a compound of Formula (I), and pharmaceutically acceptable salts thereof, and methods of using the compounds and compositions for treating diseases, such as cancer, autoimmune disorders, and inflammatory disorders.

Formation of dihydronaphthalenes via organocatalytic enatioselective michael-aldol cascade reactions with arylalkanes

An organocatalytic highly enantioselective Michael-aldol cascade access to valuable chiral dihydronaphthalenes has been realized. Notably, the strategy via activation of nucleophilic alkyl chains by introducing nitro, chloro, or CF3 group(s) at the ortho- and/or para-position(s) on an aromatic ring renders them readily deprotonated to produce highly reactive nulecophilic species in the cascade process under mild conditions.

Synthesis and Reactions of a Stable o-Quinoid 10-π-Electron System, Furo[3,4-c]pyridine

Methyl 4,6-dichloro-3-(diethylamino)furo[3,4-c]pyridine-1-carboxylate (6), an intermediate in the Hamaguchi-Ibata reaction involving the RhII-catalyzed intramolecular reaction of a diazo group with the carbonyl of an adjacent amido group, has been isolated and characterized. PM3 calculations reveal the heat of formation (ΔHf) of this remarkably stable molecule to be -77.7 kcal/mol. Compound 6 undergoes a facile Diels-Alder cycloaddition with a variety of dienophiles to give polysubstituted isoquinoline derivatives via ring opening of initially formed cycloadducts. In each case the cycloaddition proceeds with high regioselectivity, with the electron-withdrawing group located ortho to the amino group. The most favorable FMO interaction is between the HOMO of the azaisobenzofuran 6 and the LUMO of the dienophile. The atomic coefficient at the ester carbon of the azaisobenzofuran 6 is larger than the amino center, and this nicely accommodates the observed regioselectivity.