915945-39-0

Basic information

• Product Name: (E)-3-[3-Ethoxy-4-(phthaliMidyl)anilino]-N-(3-chloro-4-fluorophenyl)-2-cyano-2-propenaMide
• Synonyms: (E)-3-[3-Ethoxy-4-(phthaliMidyl)anilino]-N-(3-chloro-4-fluorophenyl)-2-cyano-2-propenaMide;(E)-N-(3-Chloro-4-fluorophenyl)-2-cyano-3-[[4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-3-ethoxyphenyl]aMino]-2-propenaMide
• CAS NO: 915945-39-0
• Molecular Formula: C₂₆H₁₈ClFN₄O₄
• Molecular Weight: 505
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 915945-39-0.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Solubility: Methanol
• CAS DataBase Reference: (E)-3-[3-Ethoxy-4-(phthaliMidyl)anilino]-N-(3-chloro-4-fluorophenyl)-2-cyano-2-propenaMide(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-[3-Ethoxy-4-(phthaliMidyl)anilino]-N-(3-chloro-4-fluorophenyl)-2-cyano-2-propenaMide(915945-39-0)
• EPA Substance Registry System: (E)-3-[3-Ethoxy-4-(phthaliMidyl)anilino]-N-(3-chloro-4-fluorophenyl)-2-cyano-2-propenaMide(915945-39-0)

Safety Data

• Hazardous Substances Data: 915945-39-0(Hazardous Substances Data)

Usage

Chemical Properties

Yellow Solid

Upstream product

• 106981-52-6 3-ethoxy-4-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)aniline 
• 122-51-0 orthoformic acid triethyl ester 
• 219529-31-4 N-(3-chloro-4-fluoro)phenyl-2-cyanoacetamide 

Downstream Products

• 915945-40-3 3-cyano-4-(3-chloro-4-fluoroanilino)-7-ethoxy-N-phthalimidyl-quinoline 

Relevant articles and documents

Method of preparing 3-cyano-quinolines and intermediates made thereby

The present invention relates to methods for preparing substituted 3-cyanoquinolines and intermediates obtained by the methods of the present invention. The methods of the invention comprise reacting an N-aryl-2-propanimide with phosphoryl chloride to produce the substituted 3-cyanoquinolines. The methods further comprise reacting arylamines, orthoformates and active methylenes to produce the N-aryl-2-propenamide.