915948-92-4

Upstream product

• 1013335-78-8 5-bromopyridine-2-carboxylic acid chloride 
• 124-40-3 dimethyl amine 
• 37131-87-6 5-bromo-2-pyrimidinecarboxylic acid 

Downstream Products

• 1352570-07-0 5-(3-isopropoxy-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide 
• 1352570-59-2 N,N-dimethyl-5-(3-(6-oxo-1,6-dihydropyrimidin-2-yl)-5-(tetrahydrofuran-3-yloxy)phenoxy)pyrimidine-2-carboxamide 
• 1352570-65-0 (S)-5-(3-(1-methoxypropan-2-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide 
• 1352570-55-8 5-(3-(cyclopentyloxy)-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide 
• 1352570-68-3 N,N-dimethyl-5-(3-(6-oxo-1,6-dihydropyrimidin-2-yl)-5-(pentan-3-yloxy)phenoxy)pyrimidine-2-carboxamide 
• 1352570-41-2 (S)-5-(3-(1-hydroxypropan-2-yloxy)-5-(6-oxo-1,6-dihydropyrimidin-2-yl)phenoxy)-N,N-dimethylpyrimidine-2-carboxamide 
• 1448788-58-6 C₂₂H₂₂N₆O₅ 

Relevant academic research and scientific papers

2-(3,5-DISUBSTITUTEDPHENYL)PYRIMIDIN-4(3H)-ONE DERIVATIVES

O N NH R3 R2 O R1 168 ABSTRACT The present invention provides a 2-(3,5-disubstitutedphenyl)pyrimidin- 4(3H)-one compound of Formula (I) 5 (I) or a pharmaceutically acceptable salt thereof wherein R 1, R2 and R3 are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and 10 the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.

Benzofuranyl Derivatives

The present invention provides compounds of Formula (I) that act as glucokinase activators; pharmaceutical compositions thereof; and methods of treating diseases, disorders, or conditions mediated by glucokinase.

SUBSTITUTED INDAZOLE AMIDES AND THEIR USE AS GLUCOKINASE ACTIVATORS

The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R4, R6, X, Y and Z are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.

2-PHENYL SUBSTITUTED IMIDAZOL [4 , 5B] PYRIDINE/ PYRAZINE AND PURINE DERIVATIVES AS GLUCOKINASE MODULATORS

Compounds of Formula (I), wherein R1- R10, A and X1 to X3 are as described in the specification, and their salts and pro-drugs, are activators of glucokinase (GLK) and are thereby useful in the treatment of, for example, type 2 diabetes. Processes for preparing compounds of formula (I) are also described.