915975-60-9Relevant articles and documents
One-Step Synthesis of the 1-Azaspiro[5.5]undecane Skeleton Characteristic of Histrionicotoxin Alkaloids from Linear Substrates via Hg(OTf)2-Catalyzed Cycloisomerization
Matsumura, Kunihiro,Nishikawa, Keisuke,Yoshida, Hiroaki,Niwa, Toshiki,Fushii, Yuichiro,Doe, Matsumi,Morimoto, Yoshiki
, p. 1882 - 1886 (2021)
Histrionicotoxin (HTX) alkaloids isolated from the poison arrow frogs possess a unique structure characterized by a 1-azaspiro[5.5]undecane skeleton common to the HTX family. The unique molecular architecture of HTXs and the interest as potential target d