91600-33-8

Basic information

• Product Name: ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE
• Synonyms: ETHYL 3-HYDROXY-2-METHYL-4,4,4-TRIFLUOROBUTYRATE;ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE;Ethyl 2-methyl-3-hydroxy-4,4,4-trifluorobutyrate~3-Hydroxy-2-methyl-4,4,4-trifluorobutyric acid ethyl ester;3-hydroxy-2-methyl-4,4,4-trifluorobutyric acid ethyl ester;Ethyl 2-methyl-3-hydroxy-4,4,4-trifluorobutyrate 95%;Ethyl2-methyl-3-hydroxy-4,4,4-trifluorobutyrate95%;Ethyl 4,4,4-trifluoro-3-hydroxy-2-methylbutyrate
• CAS NO: 91600-33-8
• Molecular Formula: C7H11F3O3
• Molecular Weight: 200.16
• Mol File: 91600-33-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 180 °C
• Flash Point: 180-184°C
• Appearance: /
• Density: 1.233 g/cm³
• Vapor Pressure: 0.0235mmHg at 25°C
• Refractive Index: 1.386
• PKA: 11.73±0.20(Predicted)
• BRN: 6194166
• CAS DataBase Reference: ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE(91600-33-8)
• EPA Substance Registry System: ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE(91600-33-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 91600-33-8(Hazardous Substances Data)

Usage

General Description

ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE is a chemical compound with the molecular formula C7H11F3O3. It is a colorless liquid with a fruity odor and is commonly used as a flavoring agent in the food industry. ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE is also used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It is important to handle this chemical with care, as it can be harmful if ingested, inhaled, or in contact with skin. Therefore, proper safety measures and precautions should be taken when working with ETHYL 2-METHYL-3-HYDROXY-4,4,4-TRIFLUOROBUTYRATE.

InChI:InChI=1/C7H11F3O3/c1-3-13-6(12)4(2)5(11)7(8,9)10/h4-5,11H,3H2,1-2H3

Upstream product

• 74-88-4 methyl iodide 
• 75-90-1 2,2,2-Trifluoroacetaldehyde 
• 535-11-5 Ethyl 2-bromopropionate 
• 344-00-3 ethyl 2-methyl-4,4,4-trifluoroacetoacetate 
• 7440-06-4 platinum 

Relevant articles and documents

Process for substituted 3-hydroxybutyrate esters

The present invention provides a solventless process for the catalytic hydrogenation of esters of 4,4,4-trihaloacetoacetic acid using a platinum catalyst in the presence of an acid or base co-catalyst to provide the analagous 3-hydroxybutyrate ester. Such 3-hydroxybutyrate esters are useful as solvents, cleaners or fine chemical intermediates.

Reaction of trifluoroacetaldehyde with some bromoesters

Reformatsky reactions of trifluoroacetaldehyde with lower bromoesters gave their corresponding adducts.The reaction of trifluoroacetaldehyde with methyl 2-(bromomethyl)acrylate gave γ-trifluoromethyl-α-methylene-γ-butyrolactone.

PREPARATION OF TRIFLUOROMETHYLATED ALLYLIC ALCOHOLS FROM TRIFLUOROACETALDEHYDE AND ORGANOMETALLIC COMPOUNDS

A number of allylic alcohols bearing a trifluoromethyl group at the α- or γ-position, and α-trifluoromethylated γ-enols and -ynols were prepared by the reaction of trifluoroacetaldehyde with a variety of organometallic compounds.Most of the Reformatsky- or Grignard-type reactions required promotion by ultrasonic irradiation.