344-00-3

Basic information

• Product Name: ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE
• Synonyms: ETHYL ALPHA-METHYL-4,4,4-TRIFLUOROACETOACETATE;ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE;Ethyl_-methyl-4,4,4-trifluoroacetoacetate,tech.;Ethyl 2-methyl-4,4,4-trifluoroacetoacetate, tech;Ethyl2-methyl-3-oxo-4,4,4-trifluorobutyrate~2-Methyl-4,4,4-trifluoroacetoaceticacidethylester;2-methyl-4,4,4-trifluoroacetoacetic acid ethyl ester;ethyl 2-methyl-3-oxo-4,4,4-trifluorobutyrate;ETHYL A-METHYL-4,4,4-TRIFLUOROACETOACETATE TECH
• CAS NO: 344-00-3
• Molecular Formula: C₇H₉F₃O₃
• Molecular Weight: 198.14
• EINECS: -0
• Mol File: 344-00-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 144 °C
• Flash Point: 47°C
• Appearance: /
• Density: 1,2 g/cm3
• Vapor Pressure: 2.42mmHg at 25°C
• Refractive Index: 1.374
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly)
• PKA: 9.02±0.35(Predicted)
• BRN: 1783620
• CAS DataBase Reference: ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE(344-00-3)
• EPA Substance Registry System: ETHYL 2-METHYL-4,4,4-TRIFLUOROACETOACETATE(344-00-3)

Safety Data

• Hazard Codes: F,Xi
• Statements: 10-36/37/38
• Safety Statements: 26-36
• RIDADR: 3272
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 344-00-3(Hazardous Substances Data)

Usage

Uses

Ethyl 2-(trifluoroacetyl)propionate, can be used in various chemical synthesis such as in the preparation of 5,6-disubstituted thiopyrimidine aryl aminothiazoles as inhibitors of the calcium-activated chloride channel TMEM16A/Ano1.

InChI:InChI=1/C7H9F3O3/c1-3-13-6(12)4(2)5(11)7(8,9)10/h4H,3H2,1-2H3

Upstream product

• 407-38-5 2,2,2-trifluoroethyl trifluoroacetate 
• 105-37-3 Ethyl propionate 
• 74-83-9 methyl bromide 
• 372-31-6 ethyl 4,4,4-trifluoroacetoacetate 
• 74-88-4 methyl iodide 
• 383-63-1 ethyl trifluoroacetate, 

Downstream Products

• 203061-92-1 (Z)-3-Benzylamino-4,4,4-trifluoro-2-methyl-but-2-enoic acid ethyl ester 
• 121749-58-4 4,4,4-trifluoro-2-(4-methoxy-benzyl)-3-oxo-butyric acid ethyl ester 
• 152595-59-0 1,2-dihydro-4-[(4-methylthiophenyl)-methyl]-5-trifluoromethyl-3H-pyrazol-3-one 
• 91600-33-8 ethyl 4,4,4-trifluoro-3-hydroxy-2-methylbutyrate 
• 1257599-51-1 C₁₂H₈Cl₂F₃N₃O 
• 1257599-63-5 C₁₂H₁₀F₃N₃O 
• 1257599-53-3 C₁₂H₈F₅N₃O 
• 1257599-55-5 C₁₂H₇F₆N₃O 
• 1257599-61-3 C₁₂H₉ClF₃N₃O 
• 425394-59-8 4-chloro-5-methyl-6-(trifluoromethyl)pyrimidine 
• 1221577-79-2 7,8-dihydro-3-methyl-2-(trifluoromethyl)pyrrolo[1,2-a]pyrimidin-4(6H)-one 
• 147750-19-4 2,5-dimethyl-6-(trifluoromethyl)-4(3H)-pyrimidinone 
• 1018481-19-0 5-methyl-2-(4-methylsulfanylphenyl)-6-trifluoromethylpyrimidin-4-ol 
• 147750-19-4 4-hydroxy-2,5-dimethyl-6-(trifluoromethyl)pyrimidine 

Relevant articles and documents

SUBSTITUTED THIOPHENYL URACILS, SALTS THEREOF AND THE USE THEREOF AS HERBICIDAL AGENTS

The invention relates to substituted thiophenyl uracils of general formula (I) or the salts (I) thereof, wherein the groups in general formula (I) are as defined in the description, and to the use thereof as herbicides, in particular for controlling weeds and/or weed grasses in crops of cultivated plants and/or as plant growth regulators for influencing the growth of crops of cultivated plants.

SUBSTITUTED 3-AZABICYCLO[3.1.0]HEXANES AS KETOHEXOKINASE INHIBITORS

Provided herein are substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors, processes to make said compounds, and methods comprising administering said compounds to a mammal in need thereof.

Synthesis and acaricidal activity of strobilurin-pyrimidine derivatives

Pyriminostrobin, a new acaricide, was discovered in our previous studies. Because introducing fluorine into organic compounds can increase bioactivity, pyriminostrobin was modified as a series of strobilurin-pyrimidine derivatives for biological screening. The compounds were characterized by 1H NMR, MS and elemental analysis. Preliminary bioassays demonstrated that compounds 7e and 7i exhibited significant control against Tetranychus cinnabarinus (Boisd.) at 0.625 mg L-1, and their acaricidal potencies were higher than pyriminostrobin in a greenhouse. The relationship between structure and acaricidal activity was also studied.