91600-55-4Relevant academic research and scientific papers
Synthesis of β-enamino acid and heteroaryl acetic acid derivatives by Pd-catalyzed carbonylation of α-chloroimines and 2-chloromethyl aza-heterocycles
Perrone, Serena,Capua, Martina,Cannazza, Giuseppe,Salomone, Antonio,Troisi, Luigino
supporting information, p. 1421 - 1424 (2016/03/12)
β-Enamino esters or amides can be synthesized in a single step by a carbonylative coupling of α-chloroimines with alcohols or amines under Pd-catalysis. The methodology has been also applied to the preparation of heteroaryl acetic acid derivatives starting from chloromethyl heteroaromatic rings containing a C-N double bond. The in situ generation of a β-imino acylpalladium species has been proposed as a key step for the process.
4-HYDROXY-2-QUINOLONES. 16. CONDENSATION OF N-R-SUBSTITUTED AMIDES OF 2-CARBOXYMALONANILIC ACID WITH o-PHENYLENEDIAMINE
Ukrainets, I. V.,Taran, S. G.,Turov, A. V.
, p. 941 - 944 (2007/10/02)
The reaction of N-R-substituted amides of 2-carboxymalonanilic acid with the equimolar amount of o-phenylenediamine was studied under conditions of thermolysis. It was established that the main products of this reaction are the corresponding amides of ben
