916047-77-3

Upstream product

• 85511-86-0 5-chloro-1H-spiro[indole-3,3'-pyrrolidine]-2,2',5'-trione 
• 100-39-0 benzyl bromide 

Downstream Products

• 916047-79-5 (1'-benzyl-5-chloro-2,2',5'-trioxo-spiro[indole-3,3'-pyrrolidin]-1-yl)-acetic acid tert-butyl ester 
• 916047-80-8 (1'-benzyl-5-chloro-2,2',5'-trioxo-spiro[indole-3,3'-pyrrolidin]-1-yl) acetic acid ethyl ester 
• 1018457-40-3 C₂₀H₁₄ClN₃O₃ 
• 916047-78-4 3-(1'-benzyl-5-chloro-2,2',5'-trioxo-spiro[indole-3,3'-pyrrolidin]-1-yl) propionic acid tert-butyl ester 

Relevant academic research and scientific papers

Discovery of a new class of potent, selective, and orally bioavailable CRTH2 (DP2) receptor antagonists for the treatment of allergic inflammatory diseases

A novel chemical class of potent chemoattractant receptor-homologous expressed on Th2 lymphocytes (CRTH2 or DP2) antagonists is reported. An initial and moderately potent spiro-indolinone compound (5) was found during a high-throughput screening campaign.

TRICYCLIC SPIRO DERIVATIVES AS CRTH2 MODULATORS

The present invention is related to the use of spiro derivatives of Formula (I) for the treatment and/or prevention of allergic diseases, inflammatory dermatoses and other diseases with an inflammatory component. Specifically, the present invention is rel