916067-33-9Relevant academic research and scientific papers
Highly diastereoselective Friedel-Crafts reaction of furans with 8-phenylmenthyl glyoxylate
Kwiatkowski, Piotr,Majer, Jakub,Chaladaj, Wojciech,Jurczak, Janusz
, p. 5045 - 5048 (2006)
(Chemical Equation Presented) The Friedel-Crafts reaction of (1R)-8-phenylmenthyl glyoxylate with variously substituted furans was found to be efficiently promoted by SnCl4 or magnesium salts with high diastereoselectivities. MgBr2 performs especially well under simple, undemanding conditions, giving both high yields and high diastereoselectivities (>90%). The reaction afforded chiral substituted furan-2-yl-hydroxyacetic acid esters, compounds of potentially high synthetic interest.
