916084-79-2Relevant academic research and scientific papers
Prodrug activation gated by a molecular "OR" logic trigger
Amir, Roey J.,Popkov, Mikhail,Lerner, Richard A.,Barbas III, Carlos F.,Shabat, Doron
, p. 4378 - 4381 (2007/10/03)
(Chemical Equation Presented) Molecules that define logic: A molecular "OR" logic gate trigger has been demon-strated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).
