916084-80-5

Upstream product

• 334999-60-9 carbonic acid 4-hydroxymethylphenyl ester 4-nitrophenyl ester 
• 55628-82-5 1-(Phenylacetyl)imidazole 
• 103-82-2 phenylacetic acid 
• 916084-79-2 (2-tert-butoxycarbonylamino-ethyl)-(2-phenylacetylamino-ethyl)-carbamic acid 4-hydroxymethyl-phenyl ester 
• 916084-77-0 [2-(2-phenylacetylamino-ethylamino)-ethyl]-carbamic acid tert-butyl ester 

Downstream Products

• 916084-82-7 pro-Dox 
• 916084-81-6 carbonic acid 4-[[2-(3-hydroxy-3-methyl-5-oxo-hexyloxycarbonylamino)-ethyl]-(2-phenylacetylamino-ethyl)-carbamoyloxy]-benzyl ester 4-nitro-phenyl ester 

Relevant academic research and scientific papers

Prodrug activation gated by a molecular "OR" logic trigger

(Chemical Equation Presented) Molecules that define logic: A molecular "OR" logic gate trigger has been demon-strated by masking a functional group in a doxorubicin prodrug with a linker that contains two cleavable substrates (input). The prodrug molecule was activated by two different enzymes to release the parent drug (see scheme; input red; output (drug) blue).