916137-31-0Relevant academic research and scientific papers
Synthesis, dihydrofolate reductase inhibition, antitumor testing, and molecular modeling study of some new 4(3H)-quinazolinone analogs
Al-Rashood, Sarah T.,Aboldahab, Ihsan A.,Nagi, Mahmoud N.,Abouzeid, Laila A.,Abdel-Aziz, Alaa A.M.,Abdel-hamide, Sami G.,Youssef, Khairia M.,Al-Obaid, Abdulrahman M.,El-Subbagh, Hussein I.
, p. 8608 - 8621 (2006)
In order to produce potent new leads for anticancer drugs, a new series of quinazoline analogs was designed to resemble methotrexate (MTX, 1) structure features and fitted with functional groups believed to enhance inhibition of mammalian DHFR activity. M
Functionalization of Quinazolin-4-Ones Part 2#: Reactivity of 2-Amino-3, 4, 5, or 6-Nitrobenzoic Acids with Triphenylphosphine Thiocyanate, Alkyl Isothiocyanates, and Further Derivatization Reactions
Heppell, Jacob T.,Al-Rawi, Jasim M. A.
, p. 1361 - 1367 (2015/02/19)
2-amino-3, 4, 5, or 6-nitrobenzoic acids were reacted with PPh3(SCN)2 and alkyl isothiocyanates to give 5, 6, 7, or 8-nitro-2-thioxo-3-substituted quinazolin-4-ones, respectively. The position of the nitro group was found to have sig
Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2
Heppell, Jacob,Al-Rawi, Jasim
, p. 162 - 174 (2014/02/14)
4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.
