951-97-3

Usage

Main properties

1. Molecular formula: C9H8N2O4
2. Appearance: Yellow crystalline solid
3. Usage: Commonly used in the synthesis of pharmaceuticals and dyes
4. Inhibitory properties: Inhibits the synthesis of folic acid
5. Potential applications: Development of antimicrobial drugs, anti-inflammatory, and analgesic properties
6. Safety precautions: Can cause skin, eye, and respiratory irritation if not handled properly

Appearance

Yellow crystalline solid

Usage

Synthesis of pharmaceuticals and dyes

Inhibitory properties

Inhibits folic acid synthesis

Potential applications

Antimicrobial drugs, anti-inflammatory, analgesic

Safety precautions

Handle with care to avoid skin, eye, and respiratory irritation.

InChI:InChI=1/C9H8N2O5/c1-5(12)10-8-4-6(11(15)16)2-3-7(8)9(13)14/h2-4H,1H3,(H,10,12)(H,13,14)

Upstream product

• 2879-79-0 N-(2-methyl-5-nitrophenyl)acetamide 
• 108-24-7 acetic anhydride 
• 619-17-0 4-Nitroanthranilic acid 
• 75-36-5 acetyl chloride 
• 99-55-8 2-methyl-5-nitroaniline 

Downstream Products

• 969-49-3 3-(3-chloro-phenyl)-2-methyl-7-nitro-3H-quinazolin-4-one 
• 103753-96-4 2-acetylamino-4-nitro-benzoic acid amide 
• 3776-42-9 2-acetylamino-4,5-dinitro-benzoic acid 
• 59156-43-3 4-amino-2-acetylamino-benzoic acid 
• 619-17-0 4-Nitroanthranilic acid 
• 55204-24-5 ethyl 2-amino-4-nitrobenzoate 
• 3558-19-8 methyl 2-amino-4-nitrobenzoate 
• 174565-63-0 7-nitro-1,2,3,4-tetrahydro-quinazoline-2,4-dione 
• 129112-65-8 2,4-dichloro-7-nitroquinazoline 
• 101257-19-6 2,5-dihydroxy-4-nitrobenzoic acid 
• 81946-23-8 2,4-diamino-5-nitro-benzoic acid 
• 98555-62-5 2-chloro-5-hydroxy-4-nitro-benzoic acid 
• 859034-06-3 5-hydroxy-2-iodo-4-nitro-benzoic acid 
• 204254-66-0 2-amino-4-methoxy-5-nitrobenzoic acid 

Relevant academic research and scientific papers

Functionalization of quinazolin-4-ones part 1: Synthesis of novel 7-substituted-2-thioxo quinazolin-4-ones from 4-substituted-2-aminobenzoic acids and PPh3(SCN)2

4-(Nitro, amino, acetylamino)-2-aminobenzoic acid were allowed to react with PPh3(SCN)2 and gave the crossholding 7-nitro, 7-acetylamino- and 7-amino-2-thioxo quinazolin-4-ones respectively. The nature of the substituent at position 4 of the 2-aminobenzoic acids has significant influence on the outcome of the cyclisation reaction with PPh 3(SCN)2. Similarly, the nature of the substituent at position 7 of the 2-substituted quinazolin-4-ones significantly affected the ease with which alkylation reactions could be performed. The alkylation selectivity of the 7- substiuted-2-thioxo quinazolin-4-ones was found to depend on the nature of the alkyl halide and the nature of the substituent at position 2.

4H-3,1-BENZOXAZIN-4-ONE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS THEREOF FOR THE INHIBITION OF SERINE PROTEASES

A 4H-3,1-benzoxazin-4-one compound of the formula (I): STR1 wherein R is a hydrogen atom or alkyl radical, A is an amino acid residue or a peptide having 2 to 3 amino acid residues, which amino acid residue may have a side chain thereof protected by a protective radical, X is an alkyl, fluoroalkyl, OR 1 or NHR 1 radical wherein R 1 is an alkyl radical, and Y is a protective radical for an amino radical, and salts thereof, exhibit an excellent inhibitory activity against serine proteases, especially against human leukocyte elastase, and thus are useful as an effective component of a medicine for inhibiting elastase.

Preparation of Some Acetylated, Reduced and Oxidized Derivatives of 2,4-Diaminotoluene and 2,6-Dinitrotoluene

4-Acetylamino-2-hydroxylaminotoluene (4AA2HAT) and 2-hydroxylamino-6-nitrotoluene (2HA6NT) were prepared from 4-acetylamino-2-nitrotoluene (4AA2NT) and 2,6-dinitrotoluene (2,6-DNT), respectively, by reduction with zinc dust and NH4Cl. 2,6-Dinitrobenzylalcohol (2,6-DNB) and 2,6-dinitrobenzoic acid (2,6-DNBA) were prepared from 2,6-dinitrobenzaldehyde (2,6-DNBAl) by reduction with NaBH4 and by oxidation with KMnO4, respectively. 2-Acetylamino-4-aminobenzoic acid (2AA4ABA) was prepared from 4-nitroanthranilic acid (4NAA) by acetylation followed by reduction with NaBH4 and Pd-C. 2,4-Diacetylaminobenzoic acid (2,4-DAABA) was prepared from 4NAA by reduction with NaBH4 and Pd-C followed by acetylation. 4-Acetylamino-2-aminobenzoic acid (4AA2ABA) was prepared from 4NAA by reduction and acetylation followed by chelation with Cu(AcO)2.Keywords- 4-acetylamino-2-hydroxylaminotoluene; 2-hydroxylamino-6-nitrotoluene; 2,6-dinitrobenzylalcohol; 2,6-dinitrobenzoic acid; 2-acetylamino-4-aminobenzoic acid; 4-acetylamino-2-aminobenzoic acid; 2,4-diacetylaminobenzoic acid; carcinogenicity; mutagenicity; preparation