916176-50-6

Usage

Uses

Used in Pharmaceutical Synthesis:
1-Tosyl-1H-pyrrolo[2,3-b]pyridine-4-boronic acid pinacol ester is used as a reagent in organic synthesis and medicinal chemistry for the development of new pharmaceuticals. Its boronic acid ester functionality allows for the formation of carbon-carbon and carbon-heteroatom bonds, facilitating the synthesis of complex molecular structures with potential therapeutic applications.
Used in Agrochemical Synthesis:
In the agrochemical industry, 1-Tosyl-1H-pyrrolo[2,3-b]pyridine-4-boronic acid pinacol ester is used as a key intermediate in the synthesis of agrochemicals, such as pesticides and herbicides. Its versatility in forming various chemical bonds enables the creation of novel compounds with improved efficacy and selectivity in controlling pests and weeds.
Used in Materials Synthesis:
1-Tosyl-1H-pyrrolo[2,3-b]pyridine-4-boronic acid pinacol ester is also utilized in the synthesis of advanced materials, such as polymers and coatings, with unique properties. Its ability to form stable bonds with a wide range of elements contributes to the development of materials with enhanced performance characteristics, such as improved durability, stability, and functionality.
Used in Drug Discovery and Development:
As a valuable tool for researchers and chemists, 1-Tosyl-1H-pyrrolo[2,3-b]pyridine-4-boronic acid pinacol ester is employed in drug discovery and development processes. Its unique structure and properties allow for the exploration of new chemical space and the identification of potential lead compounds with therapeutic potential. The tosyl group's protective effect on the boronic acid functionality further enhances its utility in the synthesis of biologically active molecules.

Upstream product

• 348640-07-3 4-bromo-1-(toluene-4-sulfonyl)-1H-pyrrolo[2,3-b]pyridine 
• 73183-34-3 bis(pinacol)diborane 
• 98-59-9 p-toluenesulfonyl chloride 
• 348640-06-2 4-bromo-7-azaindole 
• 271-63-6 7-Azaindole 
• 55052-24-9 1H-Pyrrolo[2,3-b]pyridine-7-oxide 

Downstream Products

• 916176-59-5 4-(6-fluoropyridin-2-yl)-1-tosyl-1H-pyrrolo[2,3-b]pyridine 
• 1352226-88-0 4-[4-[1-[[S(R)]-S-methylsulfonimidoyl]cyclopropyl]-6-[(3R)-3-methyl-4-morpholinyl]-2-pyrimidinyl]-1H-pyrrolo[2,3-b]pyridine 
• 1352226-87-9 4-{4-[(3R)-3-methylmorpholin-4-yl]-6-[1-((S)-S-methylsulfonimidoyl)cyclopropyl]pyrimidin-2-yl}-1H-pyrrolo[2,3-b]pyridine 
• 1352232-88-2 (3R)-3-methyl-4-(6-(1-(S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridine-4-yl)pyrimidin-4-yl)morpholine 
• 1352227-13-4 (R)-3-methyl-4-(6-((R)-S-methylsulfonimidoylmethyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine 
• 1352232-89-3 (3R)-3-methyl-4-(6-(1-((R)-S-methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)morpholine 
• 1394070-94-0 5-(4-(methylsulfonyl)benzyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)-6a,7,9,10-tetrahydro-[1,4]oxazino[3,4-h]pteridin-6(5H)-one 
• 945865-15-6 4-[1-Ethyl-3-(3-nitrophenyl)-1H-pyrazol-4-yl]-1-[(4-methylphenyl)sulfonyl]-1H-pyrrolo[2,3-b]pyridine 
• 916176-67-5 2-methyl-2-(6-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyridin-2-yl)propanitrile 

Relevant academic research and scientific papers

Pyrimidine derivative, and preparation method and application thereof

The invention discloses a compound represented by general formula (I) capable of being used as an ATR protein kinase inhibitor, and an isomer or pharmaceutically acceptable salt thereof. The compound, and the isomer or the pharmaceutically acceptable salt thereof can be used for preparing medicines for treating and/or preventing hyperproliferative diseases.

ATR INHIBITOR AND APPLICATION THEREOF

Disclosed are a compound as an ATR inhibitor and an application in preparing a drug as an ATR inhibitor. In particular, disclosed is a compound represented by formula (I) or an isomer or pharmaceutically acceptable salt thereof.

HETEROCYCLIC INHIBITORS OF ATR KINASE

The present invention relates to heterocyclic compounds and methods which may be useful as inhibitors of ATR kinase for the treatment or prevention of cancer.

Azaquinazoline Inhibitors Of Atypical Protein Kinase C

The present application provides a compound of formula (I) and/or a salt thereof, wherein R1, G, and X are as defined herein. A compound of formula (I) and/or its salts have aPKC inhibitory activity, and may be used to treat proliferative disor

SUBSTITUTED INDAZOLE COMPOUNDS AS IRAK4 INHIBITORS

The present invention provides substituted indazole compound of formula (I) and pharmaceutically acceptable salts thereof, and their use to inhibit IRAK4 and/or for the treatment of diseases or disorders induced by IRAK4.

CHEMICAL COMPOUNDS

There is provided pyrimidinyl compounds of Formula (I), wherein: R2 is or pharmaceutically acceptable salts thereof, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.

Pyrrolo [2,3,B] Pyridine Derivatives Useful As RAF Kinase Inhibitors

The present invention provides pyrrolo pyridine compounds, compositions containing the same, as well as processes for the preparation and their use as pharmaceutical agents.

Knowledge-based design of 7-azaindoles as selective B-Raf inhibitors

The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC50 = 2.5 nM) and the cellular assay (ICsub

INHIBITORS OF Akt ACTIVITY

Invented are novel thiophene compounds, the use of such compounds as inhibitors of protein kinase B activity and in the treatment of cancer and arthritis.