916176-53-9

Usage

Molecular Structure

1H-Pyrrolo[2,3-b]pyridine with a pyrrolopyridine core and a sulfonyl group attached to the nitrogen atom.

Substitution Pattern

Bromine and chlorine atoms attached to the pyrrolo ring, and a methylphenylsulfonyl group attached to the nitrogen atom.

Type of Compound

A substituted pyrrolopyridine derivative.

Potential Applications

Medicinal chemistry, specifically in the development of new drugs for the treatment of various diseases.

Value

Unique structure and functional groups make it a valuable building block for the synthesis of novel pharmaceutical compounds with potential therapeutic effects.

InChI:InChI=1/C14H10BrClN2O2S/c1-9-2-4-10(5-3-9)21(19,20)18-7-6-11-13(15)12(16)8-17-14(11)18/h2-8H,1H3

Upstream product

• 916176-52-8 4-bromo-5-chloro-1H-pyrrolo[2,3-b]pyridine 
• 98-59-9 p-toluenesulfonyl chloride 
• 866546-07-8 5-chloro-1H-pyrrolo[2,3-b]pyridine 
• 916176-51-7 5-chloro-1H-pyrrolo[2.3-b]pyridine oxide 

Relevant academic research and scientific papers

Substituted heteroaryl compound and composition and application thereof

The invention provides a substituted heteroaryl compound and a pharmaceutical composition and application thereof. The compound is a compound as shown in formula (I) or the stereisomer, tautomer, nitric oxide, solvate, metabolite, pharmaceutically acceptable salt or prodrug of the compound as shown in formula (I). The pharmaceutical composition containing the compound can regulate the activity ofprotein kinase and especially the activity of Aurora kinase and JAK kinase and is used for preventing, treating and relieving diseases or disorder mediated by protein kinase and especially JAK kinase.

SUBSTITUTED HETEROARYL COMPOUNDS AND METHODS OF USE

The present invention provides novel heteroaryl compounds, pharmaceutical acceptable salts and formulations thereof. They are useful in preventing, managing, treating or lessening the severity of a protein kinase-mediated disease. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of protein kinase-mediated disease.

PYRROLOPYRIDINES USEFUL AS INHIBITORS OF PROTEIN KINASE

The present invention relates to compounds of formula (I) wherein Q, Z, R1 , R2 , and R3 are as described in claim 1 useful as inhibitors of protein kinases, particularly of JAK family and ROCK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.