91619-31-7

Usage

Uses

Used in Pharmaceutical Industry:
1-(3-Nitrophenylsulfonyl)piperidine is used as a building block for the synthesis of various pharmaceuticals and agrochemicals. Its unique structure allows it to be a key component in the development of new drugs and pesticides.
Used in Medicinal Chemistry Research:
1-(3-Nitrophenylsulfonyl)piperidine is used as a non-peptide angiotensin receptor antagonist for the treatment of hypertension and heart failure. It has shown promising results in inhibiting the activity of certain enzymes, making it a valuable compound in the search for new therapeutic agents.
Used in Organic Chemistry:
1-(3-Nitrophenylsulfonyl)piperidine is used as a reagent in organic chemistry reactions. Its functional group can be utilized in various synthetic pathways, contributing to the development of new chemical compounds and materials.
Used in Biological Studies:
1-(3-Nitrophenylsulfonyl)piperidine is used as a molecular probe in biological studies. Its ability to interact with specific biological targets makes it a useful tool for investigating cellular processes and mechanisms, potentially leading to new insights in the understanding of diseases and the development of targeted therapies.

InChI:InChI=1/C11H14N2O4S/c14-13(15)10-5-4-6-11(9-10)18(16,17)12-7-2-1-3-8-12/h4-6,9H,1-3,7-8H2

Upstream product

• 110-89-4 piperidine 
• 121-51-7 3-nitrobenzenesulphonyl chloride 
• 98634-21-0 4-nitrophenyl 3-nitrobenzenesulfonate 
• 84752-61-4 pyridinium paratoluene sulfonic acid 
• 857784-71-5 3-nitro-N,N-bis-(3-nitro-benzenesulfonyl)-aniline 

Downstream Products

• 22184-99-2 3-(piperidine-1-sulfonyl)-phenylamine 

Relevant academic research and scientific papers

FLT3 RECEPTOR ANTAGONISTS

The invention pertains to novel FLT3receptor antagonists of general formula (1). The compounds are useful for the treatment or the prevention of pain disorders, cancer and autoimmune diseases.

Synthesis and anticandidal activity of azole-containing sulfonamides

Twenty five benzenesulfonamides containing one imidazole or triazole ring, or two imidazole or triazole rings have been synthesized and evaluated as anticandidal agents. The most active compounds were 5c, 6b, 6c, 6e, and 17b, which exhibited MIC values of 4.55-24.39 mM depending on the clinical isolate. Comparing imidazole to triazole derivatives did not show a clear effect on activity. Compounds containing a N-benzyl group also showed no clear evidence on activity given the fact that they have an extra aromatic ring. Secondary sulfonamides, 5l, 5m, and 5n showed activities that were proportional to their lipophilicity. The activities of N-aryl-substituted derivatives 5j, 5k, 5l, 5m, 5n, and 6j were also proportional to their lipophilicity. Halogenation enhanced the activity as a result of improvement of lipophilicity. The presence of two imidazole or triazole rings in the same compound did not show a clear enhancement of activity.

GLUCAGON ANTAGONISTS/INVERSE AGONISTS

A novel class of compounds, which act to antagonize the action of the glucagon hormone on the glucagon receptor. Owing to their antagonizing effect of the glucagon receptor the compounds may be suitable for the treatment and/or prevention of any glucagon-

Direct Synthesis of Sulfonamides and Activated Sulfonate Esters from Sulfonic Acids

A general new method for the preparation of sulfonamides and activated sulfonate esters by the direct coupling of sulfonic acid salts with amines and alcohols using the reagent triphenylphosphine ditriflate is described. A new reusable polymer-supported reagent for these transformations under heterogeneous conditions is also described. These methods provide a fundamentally new approach to making small molecules containing the sulfonamide functional group. Copyright