916203-67-3Relevant academic research and scientific papers
Unique tandem heck-lactamization naphthyridinone ring formation between acrylanilides and halogenated pyridines
Cvetovich, Raymond J.,Reamer, Robert A.,DiMichele, Lisa,Chung, John Y. L.,Chilenski, Jennifer R.
, p. 8610 - 8613 (2006)
The Heck coupling of acrylanilides with 4-bromo-2-chloro-3-iodo-pyridine using palladium acetate can produce bis-Heck products or undergo an unusual tandem Heck-lactamization ring formation to generate 5-chloro-1-aryl-1,6- naphthyridin-2(1H)-ones.
