91622-91-2Relevant academic research and scientific papers
Synthesis of new tetrahydropyridopyrazine derivatives via continuous flow chemistry approach and their spectroscopic characterizations
Parmar, Nilesh D.,Hadiyal, Sanjay D.,Kapupara, Vimal H.,Lalpara, Jaydeep N.,Joshi, Hitendra S.
, p. 1437 - 1445 (2021)
We report here the synthesis of different substituted tetrahydropyridopyrazine derivatives. This approach of synthesis has been designed in a way that in first simple chloro-amine coupling as an alternative of Buchwald coupling followed by heterogeneous h
Synthesis of Kappa Opioid Antagonists Based on Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence
Scarry, Sarah M.,Lovell, Kimberly M.,Frankowski, Kevin J.,Bohn, Laura M.,Aubé, Jeffrey
, p. 10538 - 10550 (2016/11/17)
The quinoxaline and quinoxalinone family of nitrogen heterocycles is present in molecules of therapeutic relevance for diverse applications ranging from infectious diseases to neuroscience targets. Here, we describe a general synthetic sequence to afford pyrrolo[1,2-α]quinoxalinones from commercially available starting materials and their use in preparing potential kappa opioid receptor antagonists. The biological data obtained from the latter set of compounds is briefly presented and discussed.
Tetrahydropyrroloquinoxalines and Tetrahydropyrrolopyridopyrazines: Vascular Smooth Muscle Relaxants and Antihypertensive Agents
Abou-Gharbia, Magid,Freed, Meier E.,McCaully, Ronald J.,Silver, Paul J.,Wendt, Robert L.
, p. 1743 - 1746 (2007/10/02)
A series of tetrahydropyrroloquinoxalines and tetrahydropyrrolopyridopyrazines were synthesized and tested for their ability to relax K+-depolarized aortic smooth muscle and antihypertensive activity.It was shown that compo
