91623-40-4Relevant academic research and scientific papers
PYRAZOLE DERIVATIVES
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Paragraph 0148, (2013/04/23)
Disclosed are compounds of general formula (I), wherein R, R1, Rc, Rd, Re, Rf, X, Y, Z, A and B are as defined in the application.
PYRAZOLE DERIVATIVES
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Paragraph 0264, (2013/06/26)
Disclosed are compounds of general formula (I), wherein R, R1, Rc, Rd, Re, Rf, X, Y, Z, A and B are as defined in the application.
Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors
Moree, Wilna J.,Goldman, Phyllis,Demaggio, Anthony J.,Christenson, Erik,Herendeen, Dan,Eksterowicz, John,Kesicki, Edward A.,McElligott, David L.,Beaton, Graham
scheme or table, p. 5126 - 5129 (2009/05/07)
A novel class of PARP-1 inhibitors was identified containing a non-aromatic heterocycle or carbocycle fused to a pyrazolo pyridin-2-one. Compounds displayed low nanomolar binding activity in the PARP-1 binding assay and submicromolar activity in a cell based chemosensitization assay.
PYRAZOLOQUINOLONES ARE POTENT PARP INHIBITORS
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Page/Page column 35, (2010/11/28)
Compounds of Formula (I) inhibit the PARP enzyme and are useful for treating a disease or a disorder associated with PARP. Also disclosed are pharmaceutical compositions comprising compounds of Formula (I), methods of treatment comprising compounds of Formula (I), and methods of inhibiting the PARP enzyme comprising compounds of Formula (I).
