916252-87-4

Basic information

• Product Name: Quinoline, 6-bromo-2-methyl-3-(methylsulfonyl)-4-phenyl-
• CAS NO: 916252-87-4
• Molecular Formula: C17H14BrNO2S
• Molecular Weight: 376.274
• Mol File: 916252-87-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Quinoline, 6-bromo-2-methyl-3-(methylsulfonyl)-4-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Quinoline, 6-bromo-2-methyl-3-(methylsulfonyl)-4-phenyl-(916252-87-4)
• EPA Substance Registry System: Quinoline, 6-bromo-2-methyl-3-(methylsulfonyl)-4-phenyl-(916252-87-4)

Safety Data

• Hazardous Substances Data: 916252-87-4(Hazardous Substances Data)

Upstream product

• 5000-46-4 1-methanesulfonyl-propan-2-one 
• 39859-36-4 2-amino-5-bromobenzophenone 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 

Relevant articles and documents

New vistas in quinoline synthesis

The gold-catalyzed Friedlander reaction was applied to the condensation of 2-aminoarylketones with β-keto-esters, β-diketones, β-keto-amides, and β-keto-sulfones to afford a diverse range of 2,3,4-trisubstituted quinolines in 3-82% yield. The seven-membered rings 1,3-cycloheptadione and azepane-2,4-dione reacted smoothly in 75% yield. An alternative procedure for the synthesis of 3-(methanesulfonyl)quinolines was developed and provided an entry into late stage manipulation of the 4-position of these quinolines. The requisite 2-aminoarylketones for the Friedlander reaction were prepared in one pot by modified Sugasawa reaction using gallium(III) chloride and boron(III) chloride in 12-54% yield.