39859-36-4

Basic information

• Product Name: 2-AMINO-5-BROMOBENZOPHENONE
• Synonyms: 5-BROMO-2-AMINOBENZOPHENONE;2-AMINO-5-BROMOBENZOPHENONE;(2-AMINO-5-BROMO-PHENYL)-PHENYL-METHANONE;2-BENZOYL-4-BROMOANILINE;IFLAB-BB F1386-0357;Methanone, (2-amino-5-bromophenyl)phenyl-;2-Benzoyl-4-bromoaniline 5-Bromo-2-aminobenzophenone;2-Amino-5-bromobenzophenone, >=97%
• CAS NO: 39859-36-4
• Molecular Formula: C₁₃H₁₀BrNO
• Molecular Weight: 276.13
• Product Categories: Aromatic Benzophenones & Derivatives (substituted);API intermediates
• Mol File: 39859-36-4.mol
• Article Data: 55

Chemical Properties

• Melting Point: 109-113℃
• Boiling Point: 424.624 °C at 760 mmHg
• Flash Point: 210.605 °C
• Appearance: Yellow/Powder
• Density: 1.484 g/cm³
• Vapor Pressure: 2.04E-07mmHg at 25°C
• Refractive Index: 1.651
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: -0.01±0.10(Predicted)
• CAS DataBase Reference: 2-AMINO-5-BROMOBENZOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-AMINO-5-BROMOBENZOPHENONE(39859-36-4)
• EPA Substance Registry System: 2-AMINO-5-BROMOBENZOPHENONE(39859-36-4)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• HazardClass: 6.1
• Hazardous Substances Data: 39859-36-4(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow Solid

Uses

2-Amino-5-bromobenzophenone is a benzophenone (B204980) derivative that is widely used in the synthesis of pharmaceutical compounds.

InChI:InChI=1/C13H10BrNO/c14-10-6-7-12(15)11(8-10)13(16)9-4-2-1-3-5-9/h1-8H,15H2

Upstream product

• 39263-32-6 2-amino-5-bromobenzonitrile 
• 138964-57-5 2-Benzenesulfonylamino-5-bromo-benzoic acid 
• 100-58-3 phenylmagnesium bromide 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 
• 71-43-2 benzene 
• 128-08-5 N-Bromosuccinimide 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 98-80-6 phenylboronic acid 
• 873-55-2 sodium benzenesulfonate 
• 7141-05-1 (2-amino-5-bromophenyl)phenylmethanol 
• 29124-57-0 2-amino-5-bromobenzaldehyde 
• 20357-20-4 5-bromo-2-nitrobenzaldehyde 
• 4692-98-2 5-bromoisatoic anhydride 
• 304854-54-4 2-amino-5-bromo-N-methoxy-N-methyl-benzamide 

Downstream Products

• 71787-43-4 N-(2-benzoyl-4-bromophenyl)acetamide 
• 1238252-01-1 N-(4-bromo-2-(1-hydroxy-1,3-diphenylprop-2-yn-1-yl)phenyl)-4-methylbenzenesulfonamide 
• 1330530-02-3 6-tert-butoxy-2-(2-methylpropyl)-4-phenylquinoline-3-carbonitrile 
• 1330529-98-0 6-hydroxy-2-(2-methylpropyl)-4-phenylquinoline-3-carbonitrile 
• 1330530-04-5 2-{[3-cyano-2-(2-methylpropyl)-4-phenylquinolin-6-yl]oxy}acetamide 
• 305864-80-6 6-bromo-4-phenylquinazoline 
• 1229609-99-7 6-bromo-2,4-diphenylquinazoline 
• 1440422-61-6 6-{4-[(E)-2-(9-anthryl)vinyl]phenyl}-4-phenyl-2-pyridin-2-ylquinoline 
• 1440422-60-5 4-phenyl-2-pyridin-2-yl-6-(4-vinyl-phenyl)-quinoline 
• 928014-00-0 6-bromo-4-phenyl-2-(pyridin-2-yl)quinolone 
• 6918-93-0 4-amino-3-benzoyl-benzonitrile 

Relevant articles and documents

Design, Synthesis, and in vitro Biological Evaluation of 3,5-Dimethylisoxazole Derivatives as BRD4 Inhibitors

BRD4 has been identified as a potential target for blocking proliferation in a variety of cancer cell lines. In this study, 3,5-dimethylisoxazole derivatives were designed and synthesized with excellent stability in liver microsomes as potent BRD4 inhibitors, and were evaluated for their BRD4 inhibitory activities in vitro. Gratifyingly, compound 11 h [3-((1-(2,4-difluorophenyl)-1H-1,2,3-triazol-4-yl)methyl)-6-(3,5-dimethylisoxazol-4-yl)-4-phenyl-3,4-dihydroquinazolin-2(1H)-one] exhibited robust potency for BRD4(1) and BRD4(2) inhibition with IC50 values of 27.0 and 180 nm, respectively. Docking studies were performed to illustrate the strategy of modification and analyze the conformation in detail. Furthermore, compound 11 h was found to potently inhibit cell proliferation in the BRD4-sensitive cell lines HL-60 and MV4-11, with IC50 values of 0.120 and 0.09 μm, respectively. Compound 11 h was further demonstrated to downregulate c-Myc levels in HL-60 cells. In summary, these results suggest that compound 11 h is most likely a potential BRD4 inhibitor and is a lead compound for further investigations.

Synthesis of substituted 2-pyridyl-4-phenylquinolines

The acid-catalyzed condensation of o-aminobenzophenones with aromatic acetyl derivatives, in a basic methanol/tetrahydrofuran medium, has been used to prepare a series of substituted 2-pyridyl-4-phenylquinolines. Derivatives having two aza binding sites can act as asymmetric bidendate ligands to complex transition metals such as ruthenium, osmium or iridium. All the compounds were characterized by elemental analysis, Ei or FAB (+) MS, 1H- and 13C-NMR spectroscopies. Complete assignments of the (1)H spectra were accomplished by using a combination of one- and two-dimensional NMR techniques.

Synthesis of 1-Amino-2,2,2-trifluoroalkylphosphonates from Alkene-Tethered Trifluoroacetimidoyl Chlorides

The reaction of alkene-tethered trifluoroacetimidoyl chlorides with trialkyl phosphites furnishes 1-amino-2,2,2-trifluoroalkylphosphonates. The products were generated in moderate to good yields, and the scalability of this process was showcased. Partial hydrolysis of the phosphonate moiety was achieved. The cyclization is proposed to occur via formation of an imidoyl phosphonate intermediate that becomes susceptible to nucleophilic attack at nitrogen through the strong electron-withdrawing groups at the imidoyl carbon.

NOVEL CELL METABOLISM MODULATING COMPOUNDS AND USES THEREOF

A class of compounds that bind to fatty acid binding protein (FABP4) and modulate adipocyte metabolism to drive enhanced glucose utilization, as well as pharmaceutical compositions comprising the class of compounds, in combination with a pharmaceutically acceptable diluent or carrier, and optionally, further in combination with a therapeutically active agent, and the use of these compounds in medicine and for the preparation of a medicament in the treatment of disorders acting on the FABP4.