91632-29-0Relevant academic research and scientific papers
New 3-unsubstituted isoxazolones as potent human neutrophil elastase inhibitors: Synthesis and molecular dynamic simulation
Giovannoni, Maria Paola,Crocetti, Letizia,Cantini, Niccolò,Guerrini, Gabriella,Vergelli, Claudia,Iacovone, Antonella,Teodori, Elisabetta,Schepetkin, Igor A.,Quinn, Mark T.,Ciattini, Samuele,Rossi, Patrizia,Paoli, Paola
, p. 338 - 349 (2020)
Human neutrophil elastase (HNE) is a proteolytic enzyme belonging to the serine protease family and is involved in a variety of pathologies. Thus, compounds able to inhibit HNE represent promising therapeutics for the treatment of inflammatory diseases. H
