916335-32-5Relevant academic research and scientific papers
Synthesis of 5-alkylidene-1,3-dioxane-4,6-diones, an easily accessible family of axially chiral alkenes: Preparation in non-racemic form and platinum binding studies
Casadesus, Meritxell,Coogan, Michael P.,Ooi, Li-Ling
, p. 3822 - 3830 (2006)
A general synthetic route to 5-alkylidene-1,3-dioxane-4,6-diones, which are a family of axially chiral alkenes, is described. Conformational issues are explored and the platinum-binding properties of these species are discussed. That these alkenes exist as stable enantiomers is established by their partial kinetic resolution upon reaction with cysteine. The Royal Society of Chemistry 2006.
