91640-73-2Relevant academic research and scientific papers
Substituted Sulfonamide Compounds
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Page/Page column 43, (2009/10/17)
Substituted sulfonamide compounds corresponding to the formula I: processes for the preparation thereof, pharmaceutical composition containing these compounds and the use of substituted sulfonamide compounds for the preparation of pharmaceutical compositions.
Substituted Sulfonamide Compounds
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Page/Page column 36, (2009/01/24)
Substituted sulfonamide compounds corresponding to formula I pharmaceutical compositions comprising them, a process for preparing them, and the use of such compounds to treat or inhibit pain and other disorders or disease states.
Synthesis and structure-activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor
Shi, Qing,Ornstein, Paul L.,Briner, Karin,Richardson, Timothy I.,Arnold, Macklin B.,Backer, Ryan T.,Buckmaster, Jennifer L.,Canada, Emily J.,Doecke, Christopher W.,Hertel, Larry W.,Honigschmidt, Nick,Hsiung, Hansen M.,Husain, Saba,Kuklish, Steve L.,Martinelli, Michael J.,Mullaney, Jeffrey T.,O'Brien, Thomas P.,Reinhard, Matt R.,Rothhaar, Roger,Shah, Jikesh,Wu, Zhipei,Xie, Chaoyu,Zgombick, John M.,Fisher, Matthew J.
, p. 2341 - 2346 (2007/10/03)
A series of benzylic piperazines (e.g., 4 and 5) attached to an 'address element', the dipeptide H-d-Tic-d-p-Cl-Phe-OH, 3 has been identified as ligands for the melanocortin subtype-4 receptor (MC4R). We describe herein the structure-activity relationship (SAR) studies on the N-terminal residue of the 'address element'. Several novel dipeptides and reduced dipeptides with high MC4R binding affinities and selectivity emerged from this SAR study.
Piperazine- and piperidine-derivatives as melanocortin receptor agonists
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Page/Page column 56, (2010/02/06)
The present invention relates to melanocortin receptor agonists of formula I, which is useful in the treatment of obesity, diabetes and male and/or female sexual dysfunction.
