91640-98-1

Upstream product

• 70770-03-5 4-(3,4-dimethoxyphenyl)-4-oxobutanenitrile 
• 14468-90-7 N-trimethylsilyl-pyrrolidin-2-one 
• 89980-69-8 3,4-dimethoxyphenylmagnesium bromide 
• 2859-78-1 4-Bromoveratrole 
• 1490305-50-4 4-azido-1-(3,4-dimethoxyphenyl)butan-1-ol 
• 76-05-1 trifluoroacetic acid 

Downstream Products

• 83314-45-8 5-(3,4-Dimethoxy-phenyl)-1-methyl-3,4-dihydro-2H-pyrrolium; iodide 
• 1315512-56-1 (+)-tert-butyl (R)-2-(3,4-dimethoxyphenyl)pyrrolidine-1-carboxylate 
• 126328-78-7 C₁₆H₁₇⁽²⁾H₄NO₂ 
• 126328-50-5 C₁₆H₁₇⁽²⁾H₄NO₂ 
• 126328-47-0 7a-(3,4-Dimethoxy-phenyl)-2-methylene-hexahydro-pyrrolizine 
• 83314-56-1 4-(3',4'-Dimethoxyphenyl)-1,1-dimethyl-azacyclo-3-hepteniumiodid 
• 83314-49-2 2-(3,4-Dimethoxy-phenyl)-1-methyl-pyrrolidine-2-carbonitrile 
• 83314-53-8 1-(3',4'-Dimethyoxyphenyl)-1-methyl-2-vinyl-pyrrolidin 

Relevant academic research and scientific papers

Intramolecular Cyclization of Brominated Oxime Ether Promoted with Ytterbium(0) to the Synthesis of Cyclic Imines

The first utility of ytterbium(0) as a mediating-metal in the intramolecular cyclization of brominated oxime ether was reported in this paper. In contrast to the prior methods, the N–O bond was used as a receptor of nucleophilic reagent, rather than as a source of N-centered radicals. Cyclic imines were obtained in this one-pot reaction with a broad scope of substrates and feasible reaction conditions.

Iminyl Radicals by Reductive Cleavage of N-O Bond in Oxime Ether Promoted by SmI2: A Straightforward Synthesis of Five-Membered Cyclic Imines

A new generation method of N-centered radicals from the reductive cleavage of the N-O bond in oxime ether promoted by SmI2 is reported for the first time. The in-situ-generated N-centered radicals underwent intramolecular cyclization to afford five-membered cyclic imines in two manners: N-centered radical addition and N-centered anion nucleophilic substitution. From a synthetic point of view, an efficient synthetic method of five-membered cyclic imines was developed. A mechanism of the transformation was proposed.

Preparation method of imine compound

The invention discloses a preparation method of an imine compound. The method comprises the following steps: under the anhydrous and anaerobic conditions, an oxime ether and a metal element are addedinto a reaction vessel in one pot, tetrahydrofuran is us

Electronic and steric effects on the intramolecular Schmidt reaction of alkyl azides with secondary benzyl alcohols

The intramolecular Schmidt reaction of simple azido secondary benzyl alcohols has been realized for the first time. Investigation of the electronic and steric effects of the substrates on the product outcome was conducted. Unique intramolecular Schmidt rearrangements were observed with the formation of a cinnamaldehyde derivative and aryl aldehydes, respectively. Using this protocol, an efficient synthesis of dihydrobenzotriazine derivatives was achieved. Moreover, a practical approach to 2-aryl-1-pyrrolines was also accessed.

Highly effective asymmetric hydrogenation of cyclic N -alkyl imines with chiral cationic Ru-MsDPEN catalysts

A range of cyclic N-alkyl imines were efficiently hydrogenated by using a chiral cationic Ru(η6-cymene)(MsDPEN)(BArF) complex (MsDPEN = N-(methanesulfonyl)-1,2-diphenylethylenediamine) in high yields and up to 98% ee. A one-pot synthesis of chiral 2-phenylpyrrolidine via reductive amination was also developed.