916441-94-6

Upstream product

• 916441-73-1 2-[4-methoxy-3-(2-trimethylsilanyl-ethoxymethoxymethyl)-phenyl]-2-methyl-propionitrile 
• 916441-62-8 [2-(5-bromo-2-methoxy-benzyloxymethoxy)-ethyl]-trimethyl-silane 
• 201150-66-5 [(5-bromo-2-methoxyphenyl)methoxy]dimethyl(1,1-dimethylethyl)silane 
• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 80866-82-6 5-bromo-2-methoxy-benzyl alcohol 

Relevant academic research and scientific papers

Substituted Pyrrolidines and Methods of Use

The invention discloses compounds of Formula (I) wherein R1, R2, R2A, R3, R3A, R4, R4A, and R5 are as defined herein. The present invention relates to compounds and their use in the treatment of cystic fibrosis, methods for their production, pharmaceutical compositions comprising the same, and methods of treating cystic fibrosis by administering a compound of the invention.

Palladium catalyzed α-arylation of methyl isobutyrate and isobutyronitrile: an efficient synthesis of 2,5-disubstituted benzyl alcohol and amine intermediates

Several 2,5-disubstituted benzyl alcohols containing a functionalized t-butyl moiety were synthesized via palladium catalyzed α-arylation of methyl isobutyrate and butyronitrile on synthetically useful scales. The resulting benzyl alcohols could then be further elaborated to benzyl amines or other desirable intermediates.