80866-82-6

Basic information

• Product Name: 5-BROMO-2-METHOXYBENZYL ALCOHOL
• Synonyms: RARECHEM AL BD 0053;5-BROMO-O-ANISYL ALCOHOL;5-BROMO-2-METHOXYBENZYL ALCOHOL;(5-BROMO-2-METHOXY-PHENYL)-METHANOL;4-BROMO-2-(HYDROXYMETHYL)ANISOLE;5-Bromo-2-methoxybenzyl alcohol 98%;5-Bromo-2-methoxybenzyl alcohol,97%;BenzeneMethanol, 5-broMo-2-Methoxy-
• CAS NO: 80866-82-6
• Molecular Formula: C₈H₉BrO₂
• Molecular Weight: 217.06
• EINECS: 279-586-7
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohol;Alcohols;Anisoles, Alkyloxy Compounds & Phenylacetates;Bromine Compounds;C7 to C8;Oxygen Compounds
• Mol File: 80866-82-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 68-71 °C(lit.)
• Boiling Point: 192.5°C (rough estimate)
• Flash Point: 134.9 °C
• Appearance: White to off-white crystalline powder
• Density: 1.4816 (rough estimate)
• Vapor Pressure: 0.000533mmHg at 25°C
• Refractive Index: 1.4930 (estimate)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-BROMO-2-METHOXYBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-BROMO-2-METHOXYBENZYL ALCOHOL(80866-82-6)
• EPA Substance Registry System: 5-BROMO-2-METHOXYBENZYL ALCOHOL(80866-82-6)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-22
• Safety Statements: 37/39-26-24/25
• WGK Germany: 3
• Hazardous Substances Data: 80866-82-6(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powder

InChI:InChI=1/C8H9BrO2/c1-11-8-3-2-7(9)4-6(8)5-10/h2-4,10H,5H2,1H3

Upstream product

• 25016-01-7 5-bromo-2-methoxybenzaldehyde 
• 612-16-8 (2-methoxyphenyl)methanol 
• 1638291-19-6 5-bromo-2-methoxy-N-methyl-N-(4-methylbenzenesulfonyl)benzenecarboxamide 
• 630050-32-7 3-bromo-N-(4-methylbenzenesulfonyl)benzenecarboxamide 
• 1638287-10-1 5-bromo-2-methoxy-N-(4-methylbenzenesulfonyl)benzenecarboxamide 
• 1711-09-7 3-bromobenzoyl chloride 
• 2316-64-5 5-bromo-2-hydroxybenzyl alcohol 
• 74-88-4 methyl iodide 
• 7017-52-9 4-bromo-2-(chloromethyl)-1-methoxybenzene 

Downstream Products

• 201150-66-5 [(5-bromo-2-methoxyphenyl)methoxy]dimethyl(1,1-dimethylethyl)silane 
• 184970-28-3 4-bromo-2-(bromomethyl)-1-methoxybenzene 
• 202822-81-9 2-methoxy-5-(1-methyl-1H-imidazol-2-yl)benzenemethanol 
• 220381-31-7 2-[3-(tert-butyl-dimethyl-silanyloxymethyl)-4-methoxy-phenyl]-1-methyl-1H-imidazole 
• 7062-40-0 1-(cyanomethyl)-2-methoxy-6-bromobenzene 
• 149488-99-3 2-(2-methoxy-5-bromophenyl)-1-aminoethane 
• 163813-58-9 N-<2-(2-methoxy-5-bromophenyl)ethyl>acetamide 
• 1009303-77-8 [2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol 
• 1227833-80-8 3-(3-hydroxymethyl-4-methoxyphenyl)pyridine 
• 505070-85-9 1-(3-dimethylaminomethyl-4-methoxyphenyl)ethanone 
• 7078-90-2 (5-bromo-2-methoxybenzyl)dimethylamine 
• 916441-67-3 2-[4-methoxy-3-(2-trimethylsilanyl-ethoxymethoxymethyl)-phenyl]-2-methyl-propionic acid methyl ester 
• 916441-73-1 2-[4-methoxy-3-(2-trimethylsilanyl-ethoxymethoxymethyl)-phenyl]-2-methyl-propionitrile 
• 916441-86-6 2-(3-hydroxymethyl-4-methoxy-phenyl)-2-methyl-propionic acid methyl ester 

Relevant articles and documents

Dehydroxymethyl Bromination of Alkoxybenzyl Alcohols by Using a Hypervalent Iodine Reagent and Lithium Bromide

We describe the dehydroxymethylbromination of alkoxybenzyl alcohol by using a hypervalent iodine reagent and lithium bromide in F 3 CCH 2 OH at room temperature. Selective monobromination or dibromination was possible by adjusting the molar ratios of hypervalent iodine reagent and lithium bromide.

New method of synthesis and biological evaluation of some combretastatin A-4 analogues

A series of novel combretastatin A-4 analogues was synthesized in 36-64% yields by Negishi cross-coupling reaction under mild conditions. The prepared compounds exhibit good cytotoxicity against HBL100 epithelial cell lines (IC50=0.022-10.31 ). Georg Thieme Verlag Stuttgart · New York.

3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3, 4-oxadiazol-2(3H)-one, BMS-191011: Opener of large-conductance Ca 2+-activated potassium (maxi-K) channels, identification, solubility, and SAR

Compound 8a (BMS-191011), an opener of the cloned large-conductance, Ca2+-activated potassium (maxi-K) channel, demonstrated efficacy in in vivo stroke models, which led to its nomination as a candidate for clinical evaluation. Its maxi-K channel opening properties were consistent with its structural topology, being derived by combining elements from other known maxi-K openers. However, 8a suffered from poor aqueous solubility, which complicated elucidation of SAR during in vitro evaluation. The activity of 8a in in vivo stroke models and studies directed toward improving its solubility are reported herein. Enhanced solubility was achieved by appending heterocycles to the 8a scaffold, and a notable observation was made that inclusion of a simple amino group (anilines 8k and 8l) yielded excellent in vitro maxi-K ion channel opening activity and enhanced brain-to-plasma partitioning compared to the appended heterocycles.