91646-45-6

Usage

Uses

Used in Pharmaceutical Industry:
1-[4-(2-AMINOPHENYL)PIPERAZIN-1-YL]ETHANONE is used as a potential therapeutic agent for the treatment of anxiety and depression, given its demonstrated anxiolytic and antidepressant effects. Its ability to modulate mood and behavior makes it a candidate for further research and development in psychopharmacology.
Used in Neurological Disorders Treatment:
In the field of neurology, 1-[4-(2-AMINOPHENYL)PIPERAZIN-1-YL]ETHANONE is considered for its potential applications in managing disorders such as schizophrenia and obsessive-compulsive disorder, where its pharmacological properties could contribute to symptom management and improvement in patient outcomes.
Used in Medicinal Chemistry:
1-[4-(2-AMINOPHENYL)PIPERAZIN-1-YL]ETHANONE serves as a valuable building block in the synthesis of biologically active molecules. Its structural features make it a key component in the creation of new compounds with potential medicinal applications, thus playing a crucial role in drug discovery and development processes.

InChI:InChI=1/C12H17N3O/c1-10(16)14-6-8-15(9-7-14)12-5-3-2-4-11(12)13/h2-5H,6-9,13H2,1H3

Upstream product

• 170017-73-9 1-[1,1-Dimethylethoxycarbonyl]-4-(2-nitrophenyl)piperazine 
• 13889-98-0 N-acetylpiperidine 
• 1493-27-2 ortho-nitrofluorobenzene 
• 100138-76-9 1-(4-(2-nitrophenyl)piperazin-1-yl)ethanone 
• 88-73-3 2-Chloronitrobenzene 
• 59084-06-9 1-(2-nitrophenyl)piperazine 

Downstream Products

• 508233-74-7 vortioxetine 
• 960203-27-4 Vortioxetine hydrobromide 
• 150557-82-7 1-(4-(2-chlorophenyl)piperazin-1-yl)ethan-1-one 

Relevant academic research and scientific papers

Synthesis and structure-activity relationships of new 2-phenoxybenzamides with antiplasmodial activity

The 2-phenoxybenzamide 1 from the Medicines for Malaria Venture Malaria Box Project has shown promising multi-stage activity against different strains of P. falciparum. It was successfully synthesized via a retrosynthetic approach. Subsequently, twenty-one new derivatives were prepared and tested for their in vitro activity against blood stages of the NF54 strain of P. falciparum. Several insights into structure-activity relationships were revealed. The antiplasmodial activity and cytotoxicity of compounds strongly depended on the substitution pattern of the anilino partial structure as well as on the size of substituents. The diaryl ether partial structure had further impacts on the activity. Additionally, several physicochemical and pharmacokinetic parameters were calculated (log P, log D7.4 and ligand efficiency) or determined experimentally (passive permeability and CYP3A4 inhibition). The tert-butyl-4-{4-[2-(4-fluorophenoxy)-3-(trifluoromethyl)benzamido]phenyl}piperazine-1-carboxylate possesses high antiplasmodial activity against P. falciparum NF54 (PfNF54 IC50 = 0.2690 μM) and very low cytotoxicity (L-6 cells IC50 = 124.0 μM) resulting in an excellent selectivity index of 460. Compared to the lead structure 1 the antiplasmodial activity was improved as well as the physicochemical and some pharmacokinetic parameters.

NEW VORTIOXETINE INTERMEDIATE AND SYNTHESIS PROCESS THEREOF

The present invention provides a new intermediate II and a method for synthesizing the same. The method comprises: (a) firstly diazotizing a compound of formula I as a raw material, and then halogenating to obtain an intermediate II; and (b) reacting the

SYNTHESIS OF VORTIOXETINE VIA (2-(PIPERAZINE-1 -YL)PHENYL)ANILINE INTERMEDIATES

The present invention provides a new synthetic process for the production of 1-(2-((2,4- dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)aniline intermediates.

Synthesis of vortioxetine via (2-(piperazine-1-yl)phenyl)aniline intermediates

The present invention provides a new synthetic process for the production of 1-(2-((2,4-dimethylphenyl)thio)phenyl)piperazine (vortioxetine), a drug for the treatment of depression and anxiety, which is conducted via (2-(piperazine-1-yl)phenyl)aniline intermediates.