150557-82-7

Upstream product

• 39512-50-0 N-(o-Chlorophenyl)piperazine 
• 108-24-7 acetic anhydride 
• 60-35-5 acetamide 
• 41202-32-8 1-(2-chlorophenyl)piperazine hydrochloride 
• 91646-45-6 1-(4-(2-aminophenyl)piperazin-1-yl)ethanone 
• 100138-76-9 1-(4-(2-nitrophenyl)piperazin-1-yl)ethanone 
• 95-51-2 o-chloroaniline 

Downstream Products

• 144514-41-0 2-{[3-(4-Acetyl-piperazin-1-yl)-4-chloro-phenylamino]-methoxymethylsulfanyl-methylene}-malonic acid diethyl ester 
• 144514-40-9 diethyl<<3-(4-acetyl-1-piperazinyl)-4-chlorophenyl>-amino>mercaptomethylenemalonate 
• 144514-39-6 3-(4-acetyl-1-piperazinyl)-4-chlorophenyl isothiocyanate 
• 144514-38-5 3-(4-acetyl-1-piperazinyl)-4-chloroaniline 
• 144514-36-3 1-acetyl-4-(2-chloro-5-nitrophenyl)piperazine 

Relevant academic research and scientific papers

An Environmentally Benign, Catalyst-Free N?C Bond Cleavage/Formation of Primary, Secondary, and Tertiary Unactivated Amides

Herein, we report an operationally simple, cheap, and catalyst-free method for the transamidation of a diverse range of unactivated amides furnishing the desired products in excellent yields. This protocol is environmentally friendly and operates under extremely mild conditions without using any promoter or additives. Significantly, this strategy has been implied in the chemoselective synthesis of a pharmaceutical molecule, paracetamol, on a gram-scale with excellent yield. We anticipate that this universally applicable strategy will be of great interest in drug discovery, biochemistry, and organic synthesis.

NEW VORTIOXETINE INTERMEDIATE AND SYNTHESIS PROCESS THEREOF

The present invention provides a new intermediate II and a method for synthesizing the same. The method comprises: (a) firstly diazotizing a compound of formula I as a raw material, and then halogenating to obtain an intermediate II; and (b) reacting the

Antiviral agent

An antiviral agent containing a compound represented by formula (I): wherein R1 represents a substituted or unsubstituted alkyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted arylsulfonyl group, a substituted o