916503-04-3Relevant academic research and scientific papers
Para substituted benzaldehydes as expedient reagents for the oxidative aromatization of hydroquinoline
Majumdar, Poulomi,Pati, Anita,Behera, Rajani K.,Behera, Ajaya Kumar
, p. 703 - 712 (2013)
A Cannizzaro-type reaction of tetrahydro-5(1H)-quinolinones with para substituted benzaldehydes in the presence of a base formed the corresponding quinoline and aryl methanol rather than arylidene derivatives because of the oxidation of tetrahydroquinoline and reduction of benzaldehydes as a result of unprecedented hydride transfer from tetrahydroquinoline to arylaldehydes. The reaction proceeds best with the participation of substituents with +M effect in substrate molecule.
Design and synthesis of 2,4-disubstituted polyhydroquinolines as prospective antihyperglycemic and lipid modulating agents
Kumar, Atul,Sharma, Siddharth,Tripathi, Vishwa Deepak,Maurya, Ram Awatar,Srivastava, Swayam Prakash,Bhatia, Gitika,Tamrakar,Srivastava, Arvind Kumar
experimental part, p. 4138 - 4148 (2010/08/06)
A series of 2,4-disubstituted polyhydroquinoline were synthesized and evaluated for their in vivo antihyperglycemic as well as antidyslipidemic activities. Several synthesized compounds have exhibited promising in vivo antihyperglycemic in SLM, STZ-S, and db/db mice model along with significant lipid and TG modulating activity. All these compounds were evaluated in various in vitro models of diabetes to know the possible mechanism of their antihyperglycemic action. Interestingly, compounds 3a-r (diaryl substitution) have exhibited promising protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity whereas, compounds 5a-d (acid substituted) have shown significant glycogen phosphorylase activity.
