91652-67-4Relevant academic research and scientific papers
C1 substituted 3, 4 - ISO-quinoline alkaloids of the preparation and its medicinal use
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Paragraph 0124; 0130; 0131; 0156; 0157; 0158, (2019/03/28)
The invention belongs to the field of medical technology. The invention relates to a structure of the formula (I) indicated by the C1 substituted 3, 4 - ISO alkaloid or its pharmaceutically acceptable salt preparation method and medical use thereof. The invention to BOC - L - phenylalanine as raw materials, with 3, 4 - dimethoxyphenethylamine to N - acylated condensation and then remove the BOC group gets the (S)- 2 - amino - N - (3, 4 - dimethyl practiced with ethyl) - 3 - benzyl amide intermediate 1, intermediate 1 or phenethylamine derivatives with the prepared containing different substituent phenyllacetyl carries out amidation reaction, finally loop Bischler - Napieralski reaction. After activeness screening tests, the compounds of this invention possess pancrelipase inhibition, in the development into a lipase inhibitor and for preventing or treating hyperlipidemia, diabetes, obesity or metabolic syndrome and other diseases has a good application prospect.
A NEW PREPARATION OF AN OCHOTENSIN-TYPE ISOQUINOLINE BY PHOTOLISYS
Hirai, Yoshiro,Egawa, Hiroyuki,Yamazaki, Takao
, p. 1359 - 1362 (2007/10/02)
The photolysis of 1-benzoyl-3,4-dihydroisoquinoline hydrochlorides (3) and (4) gave spirobenzylisoquinolines (5) and (6).
