91657-31-7Relevant academic research and scientific papers
Palladium-catalyzed selective C-H benzylation towards functionalized azoles with a quaternary carbon center
Xie, Pan,Huang, Hanmin,Xie, Yinjun,Guo, Shengmei,Xia, Chungu
, p. 1692 - 1700 (2012/08/14)
The direct C-H benzylation of azoles with benzyl chlorides proceeds efficiently, via sequential cleavage of one sp2 C-H bond and two sp3 C-H bonds in the presence of a palladium catalyst, to generate a wide range of tribenzylated azoles with a quaternary carbon center efficiently. The same catalyst could also promote the mono- and di-benzylation reactions through fine turning of the base and reaction conditions. Copyright
Copper-catalyzed direct benzylation or allylation of 1,3-azoles with N -tosylhydrazones
Zhao, Xia,Wu, Guojiao,Zhang, Yan,Wang, Jianbo
supporting information; experimental part, p. 3296 - 3299 (2011/04/24)
Cu-Catalyzed cross-coupling of N-tosylhydrazones with 1,3-azoles leads to the direct C-H benzylation or allylation. Cu carbene migratory insertion is proposed to play the key role in this transformation.
Palladium-catalyzed direct benzylation of azoles with benzyl carbonates
Mukai, Tomoya,Hirano, Koji,Satoh, Tetsuya,Miura, Masahiro
supporting information; experimental part, p. 1360 - 1363 (2010/05/19)
"Chemical Equation Presented" The direct aromatic sp2 C-H benzylation of azole compounds with benzyl carbonates proceeds efficiently in the presence of a Pd2(dba)3/dppp catalyst system and KaOAc as a base to afford the corresponding diarylmethanes in good yields. In addition, the same palladium catalyst enables the direct benzylic sp3 C-H benzylation with the second benzyl carbonates without employing any external base.
