91658-85-4Relevant academic research and scientific papers
Antimicrobial Evaluation of New Quinoxaline Derivatives Synthesized by Selective Coupling with Alkyl Halides and Amino Acids Esters
Boraei, Ahmed T. A.,El Tamany, El Sayed H.,Ali, Ibrahim A. I.,Gebriel, Sara M.
, p. 2881 - 2888 (2017/09/26)
Alkylation of quinoxaline scaffold 1 in the presence of K2CO3 preferred N-alkylation than O-alkylation. Quinoxaline hydrazide 6 was successfully coupled with various amino acids, esters, and amines via azide-coupling method. New heterocyclic compounds containing quinoxaline linked to 1,3,4-oxadiazolethione or pyrazole were obtained from cyclization of 6 with CS2 and acetylacetone, respectively. A series of hydrazide Schiff's bases were formed from hydrazide 6 by condensation with a set of aldehydes and ketones. NMR spectroscopy and mass spectrometry were used for structure elucidation of new compounds. The antimicrobial activity of the synthesized compounds was investigated toward two wild-type bacterial strains (Staphylococcus aureus and Escherichia coli) and two fungal species (Alternaria brassicicola and Fusarium oxysporum). Four compounds displayed a significant activity toward S.?aureus. The ester 4 showed higher activity than the standard drugs, which make it a promising lead compound.
Investigation of the reaction of N-acetylindoxyl with substituted anilines. Synthesis of derivatives of indolo[3,2-b]quinolines
Tugusheva,Ryabova,Solov'eva,Anisimova,Granik
, p. 885 - 893 (2007/10/03)
1-Acetyl-2,3-dihydrospiro[indolo-3, 2′-(1′,2′,3′, 4′-tetrahydroquinazolin-4′-one) was obtained from the reaction with anthranilamide, and 3-(2′-acetylaminophenyl)quinoxalin-2-one from the reaction with o-phenylenediamine, along with the normal products of the condensation of N-acetylindoxyl with substituted anilines. Derivatives of indolo[3,2-b]quinoline were synthesized from the obtained condensation products.
REACTION OF o-PHENYLENEDIAMINE WITH ISATINS
Ivashchenko, A. V.,Drushlyak, A. G.,Titov, V. V.
, p. 537 - 542 (2007/10/02)
It is shown that the reaction of o-phenylenediamine with isatins in the general case leads to mixtures of indoloquinoxalines, 3-(2'-aminophenyl)-2(1H)-quinoxalinones, and spiro.Spiro2H-benzimidazole-2,3'-in
Reaction of N-Acylisatins with Diamines
Joshi, B. S.,Likhate, M. A.,Viswanathan, N.
, p. 114 - 116 (2007/10/02)
The reaction of N-acylisatins with aromatic and heterocyclic 1,2-diamines results in opening of the N-C2 bond and leads to the 2-o-acetamidophenylquinoxaline derivatives (6) and (7).With ethylenediamine and 1,3-diaminopropane, compounds (9a) and (9b) resp
