916596-70-8Relevant academic research and scientific papers
Synthesis of a 1,2-: Cis -indoxyl galactoside as a chromogenic glycosidase substrate
Nagata, Sakuto,Tomida, Hirotaka,Iwai-Hirose, Haruka,Tanaka, Hide-Nori,Ando, Hiromune,Imamura, Akihiro,Ishida, Hideharu
, p. 28241 - 28247 (2019/09/30)
A synthetically challenging 1,2-cis-indoxyl galactoside, X-α-galactoside, was first prepared in this study using a cyclic ketone indoxyl acceptor and a glycosyl trichloroacetimidate donor to produce an enol glycoside and a 4,6-O-di-tert-butylsilylene-protected galactosyl donor to complete the synthesis. The target compound shows enzyme activity in the presence of α-galactosidase.
A concise synthesis of globotriaosylsphingosine
Gold, Henrik,Boot, Rolf G.,Aerts, Johannes M.F.G.,Overkleeft, Herman S.,Codee, Jeroen D.C.,Van Der Marel, Gijs A.
experimental part, p. 1652 - 1663 (2011/05/16)
Globotriaosylsphingosine (lysoCTH) is produced in the cell by deacylation of the globo-sphingolipid globotriaosylceramide. The latter compound is the major storage material encountered in Fabry patients, an inherited lysosomal storage disorder characteriz
