916646-21-4Relevant academic research and scientific papers
4-Amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes as potent FLT-3 inhibitors
Gaul, Micheal D.,Xu, Guozhang,Kirkpatrick, Jennifer,Ott, Heidi,Baumann, Christian A.
, p. 4861 - 4865 (2008/02/12)
A series of 4-amino-6-piperazin-1-yl-pyrimidine-5-carbaldehyde oximes has been discovered and developed as potent FLT3 tyrosine kinase inhibitors. The series exhibited potent antiproliferative activity against both an FLT3 ITD-mutated human leukemic cell line as well as a wild-type FLT3 BaF3 expressed cell line. The structure-activity relationship of this class of compounds is described.
