916659-49-9Relevant academic research and scientific papers
Enantioselective alkynylation reactions to substituted benzaldehyde and salicylaldehyde derivatives: The effect of substituents upon the efficiency and enantioselectivity
Tyrrell, Elizabeth,Tesfa, Kibur Hunie,Mann, Alastair,Singh, Kuldip
, p. 1491 - 1498 (2007)
Asymmetric alkynylation reactions to mono-, di-, and trisubstituted aromatic aldehydes have been accomplished in good yields and with a range of selectivities. For salicylaldehyde derivatives both the yield and the enantioselectivity of the alkynylation r
The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators
Tyrrell, Elizabeth,Tesfa, Kibur Hunie,Greenwood, Iain,Mann, Alistair
, p. 1237 - 1240 (2008/09/21)
A range of novel benzopyrans have been synthesised and biologically evaluated for KATP channel activity employing cromakalim 1 as a benchmark KATP channel opener. Although the compounds that were evaluated demonstrated a reduced ability to relax phenylephrine stimulated rat thoracic tissue, we provide evidence that benzopyrans 7a-h may be operating via an alternative mechanism than ATP-sensitive K+ channel activity.
A study into asymmetric Nicholas cyclisation reactions
Tyrrell, Elizabeth,Millet, Julien,Tesfa, Kibur Hunie,Williams, Neil,Mann, Alastair,Tillett, Caroline,Muller, Christophe
, p. 12769 - 12778 (2008/03/28)
Three systematic approaches have been employed to investigate asymmetric Nicholas reactions. We found that the use of a chiral N-enoyl derivative provided acceptable levels of selectivity for an intermolecular Nicholas reaction, however, we were unable to identify an auxiliary that could be utilized in an asymmetric conjugate addition and a tandem inter/intramolecular series of Nicholas reactions. The use of chiral pool non-racemic propargyl alcohols, derived from citronellal, provided enhanced levels of selectivity. As a result of these studies we developed a series of Nicholas cyclisations derived from chiral non-racemic salicylaldehyde derivatives. These underwent an extremely rapid and highly efficient cyclisation, under Nicholas conditions, to afford a range of benzopyrans. The adjacent stereogenic centres appear to be formed with high levels of stereocontrol.
Enantioselective alkynylation reactions to aldehydes: The effects of aromatic substituents upon the enantioselectivity
Tyrrell, Elizabeth,Tesfa, Kibur Hunie,Millet, Julien,Muller, Christophe
, p. 3099 - 3105 (2008/02/10)
Asymmetric alkynylation reactions to linear alkyl and substituted aromatic aldehydes have been accomplished in good yields and with a range of selectivities. For aromatic aldehydes we observed that the selectivity of the alkynylation reaction appears to d
