916659-56-8Relevant academic research and scientific papers
The use of COP-OAc in the catalyst-controlled syntheses of 1,3-polyols
Kirsch, Stefan F.,Klahn, Philipp,Menz, Helge
supporting information; experimental part, p. 3592 - 3603 (2011/12/21)
An iterative strategy to the 1,3-polyol motif is described. The use of the catalytic asymmetric Overman esterification for the construction of all stereogenic centers is broadly examined as are the sequences to extend the developing polyol chain. The iterative strategies are applied to the total syntheses of rugulactone and polyrhacitides A and B. 1 Introduction 2 Results and Discussion 2.1 Chain Elongation via RCM (Cycle A) 2.2 Total Synthesis of Rugulactone 2.3 Chain Elongation via Ando Olefination (Cycle B) and Total Syntheses of Polyrhacitides A and B 2.4 Useful Variants 3 Conclusions. Georg Thieme Verlag Stuttgart. New York.
A concise and efficient stereoselective synthesis of the C1-C11 fragment of macrolactin A
Bonini, Carlo,Chiummiento, Lucia,Videtta, Valeria,Colobert, Fran?oise,Solladié, Guy
, p. 2427 - 2430 (2008/02/10)
A stereoselective synthesis of the C1-C11 fragment of macrolactin A, using original approaches for the introduction of the Z,E-diene stereochemistry and the C-7 stereogenic center, is reported. The adopted strategy has allowed us to build up the fragment
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide
Smith III, Amos B.,Freeze, B. Scott,LaMarche, Matthew J.,Hirose, Tomoyasu,Brouard, Ignacio,Rucker, Paul V.,Xian, Ming,Sundermann, Kurt F.,Shaw, Simon J.,Burlingame, Mark A.,Horwitz, Susan Band,Myles, David C.
, p. 311 - 314 (2007/10/03)
(Chemical Equation Presented) The design, syntheses, and biological evaluation of 22 totally synthetic analogues of the potent microtubule- stabilizing agent (+)-discodermolide (1) have been achieved. Structure-activity relationships of the C(19) carbamat
Design, synthesis, and evaluation of analogues of (+)-14- normethyldiscodermolide
Smith III, Amos B.,Freeze, B. Scott,LaMarche, Matthew J.,Hirose, Tomoyasu,Brouard, Ignacio,Xian, Ming,Sundermann, Kurt F.,Shaw, Simon J.,Burlingame, Mark A.,Horwitz, Susan Band,Myles, David C.
, p. 315 - 318 (2007/10/03)
(Chemical Equation Presented) The design, syntheses, and biological evaluation of nine totally synthetic analogues of the microtubule-stabilizing agent (+)-14-normethyldiscodermolide (2) are reported. Simplification at the C(21)-C(24) terminal diene and a
