916730-76-2Relevant academic research and scientific papers
Synthesis and evaluation of the first cis-cyclobutane-containing receptor for lipid A
Bucholtz, Kevin M.,Gareiss, Peter C.,Tajc, Stephen G.,Miller, Benjamin L.
, p. 3973 - 3979 (2006)
The first example of a designed receptor containing a cis-1,3-disubstituted cyclobutane ring has been synthesized. This molecule binds diphosphoryl lipid A (a conserved portion of the Gram-(-) bacterial cell membrane, and the causative agent of septic shock) with an affinity comparable to previously described ter-cycloalkane based lipid A-binding compounds. The Royal Society of Chemistry 2006.
