916737-76-3

Basic information

• Product Name: 6-Bromo-3-methoxy-2-nitro-pyridine
• Synonyms: 6-Bromo-3-methoxy-2-nitro-pyridine;6-BROMO-3-METHOXY-2-NITROPYRIDINE(WX191671)
• CAS NO: 916737-76-3
• Molecular Formula: C₆H₅BrN₂O₃
• Molecular Weight: 233.03
• Mol File: 916737-76-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 360.9°C at 760 mmHg
• Flash Point: 172.1°C
• Appearance: /
• Density: 1.73g/cm³
• Vapor Pressure: 4.47E-05mmHg at 25°C
• Refractive Index: 1.586
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 6-Bromo-3-methoxy-2-nitro-pyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-3-methoxy-2-nitro-pyridine(916737-76-3)
• EPA Substance Registry System: 6-Bromo-3-methoxy-2-nitro-pyridine(916737-76-3)

Safety Data

• Hazardous Substances Data: 916737-76-3(Hazardous Substances Data)

Usage

General Description

6-Bromo-3-methoxy-2-nitro-pyridine is a chemical compound with the molecular formula C6H5BrN2O3. It is a pyridine derivative and contains a bromine, methoxy, and nitro functional groups. 6-Bromo-3-methoxy-2-nitro-pyridine is often used as an intermediate in the synthesis of pharmaceuticals and other organic compounds. It has been studied for its potential pharmacological and biological activities, including its antimicrobial and antifungal properties. 6-Bromo-3-methoxy-2-nitro-pyridine is also used in research and development laboratories for its unique chemical properties and is widely commercially available for various chemical applications.

InChI:InChI=1/C6H5BrN2O3/c1-12-4-2-3-5(7)8-6(4)9(10)11/h2-3H,1H3

Upstream product

• 15128-82-2 3-hydroxy-2-nitropyridine 
• 20265-37-6 3-methoxy-2-nitropyridine 
• 74-88-4 methyl iodide 
• 443956-08-9 6-bromo-2-nitropyridin-3-ol 

Downstream Products

• 952289-01-9 cis-3,5-dimethyl-1-[5-(methyloxy)-6-nitro-2-pyridinyl]piperazine 
• 443956-08-9 6-bromo-2-nitropyridin-3-ol 
• 1454928-28-9 1-(4-(tert-butyl)benzyl)-4-ethyl-3-(3-(4-(5-methoxy-6-nitropyridin-2-yl)phenyl)propyl)-1H-1 ,2,4-triazol-5(4H)-one 
• 1454926-07-8 3-{3-[4-(6-amino-5-methoxy-(2-pyridyl))phenyl]propyl}-1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-4,5-dihydro-1H-1,2,4-triazolin-5-one 
• 1454926-08-9 1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one 
• 1454926-60-3 1-{[4-(tert-butyl)phenyl]methyl}-4-ethyl-3-[3-(4-{5-methoxy-6-[N-methyl(phenylsulfonyl)amino](2-pyridyl)}phenyl)propyl]-4,5-dihydro-1H-1,2,4-triazolin-5-one 
• 916737-77-4 6-bromo-3-methoxypyridin-2-amine 
• 1438286-83-9 3-methoxy-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridin-2-amine 
• 1438286-71-5 3-methoxy-2-nitro-6-(1-(3,4,5-trimethoxyphenyl)vinyl)pyridine 
• 953392-43-3 N₁-[6-({[3-fluoro-4-(5-methyl-2-furanyl)phenyl]sulfonyl}amino)-5-(methyloxy)-2-pyridinyl]-2-methylalaninamide hydrochloride 
• 953392-13-7 1,1-dimethylethyl (2-{[6-{[(4-bromo-3-fluorophenyl)sulfonyl]amino}-5-(methyloxy)-2-pyridinyl]amino}-1,1-dimethyl-2-oxoethyl)carbamate 

Relevant articles and documents

OREXIN RECEPTOR ANTAGONISTS

The disclosures herein relate to novel compounds of formula wherein W, X and Y1, Y2, Y3 and Y4 are defined herein, and their use in treating, preventing, ameliorating, controlling or reducing the risk of neurological or psychiatric disorders associated with orexin receptors.

An efficient coupling of N-tosylhydrazones with 2-halopyridines: Synthesis of 2-α-styrylpyridines endowed with antitumor activity

The synthesis of 2-α-styrylpyridines has been carried out by using the coupling of polyoxygenated N-tosylhydrazones with various 2-halopyridines. We demonstrated that the use of a catalytic amount of PdCl2(MeCN) 2 in combination with a bidentate ferrocene DPPF or a monodentate alkyl phosphine tBu2MeP-HBF4 constitutes an efficient protocol for this coupling, providing 2-α-styrylpyridines 2 in satisfactory to good yields. Among several polyoxygenated derivatives 2 evaluated, compound 2aa was found to exhibit excellent antiproliferative and antimitotic activities comparable to that of the reference compound isoCA-4. The Royal Society of Chemistry 2013.

NOVEL COMPOUNDS

The present invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing the same and to their use in the treatment of gastrointestinal and other disorders.