916764-57-3

Upstream product

• 41715-31-5 3-tert-butyl-5-methylsalicylaldehyde 
• 2409-55-4 2-tert-Butyl-4-methylphenol 
• 72357-42-7 3-tert-butyl-5-methylsalicylaldoxime 

Downstream Products

• 1337458-43-1 (S)-2-(tert-butyl)-6-(4-isopropyl-4,5-dihydrooxazol-2-yl)-4-methylphenol 
• 1337458-54-4 2-(tert-butyl)-6-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)-4-methylphenol 

Relevant academic research and scientific papers

Facile one-pot transformation of phenols into o-cyanophenols

The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.

A general and convenient route to oxazolyl ligands

A diverse range of chiral and achiral oxazolyl ligands, which have many applications including catalysis and luminescent devices, are synthesized simply in three steps from readily available and inexpensive phenol and amino alcohol starting materials. The method can be applied to ligands with electron-donating/-withdrawing and sterically demanding/undemanding substituents, and can conveniently be scaled up to >25 g of product.