41715-31-5

Upstream product

• 2409-55-4 2-tert-Butyl-4-methylphenol 
• 201230-82-2 carbon monoxide 
• 123-63-7 paracetaldehyde 
• 106-44-5 p-cresol 
• 100-97-0 hexamethylenetetramine 
• 50-00-0 formaldehyd 

Downstream Products

• 133295-77-9 (1R,2R)-N,N'-bis(3'-tert-butyl-5'-methylsalicylidene)-1,2-diphenyl-ethylenediimine 
• 139526-27-5 [Salen^t-Bu,Me]H₂ 
• 135616-38-5 (R,R)-2,2'-[(1,2-cyclohexanediyl)bis(nitrilomethylidyne)]-bis(4-mtrhyl-6i-tert-butyl)phenol 
• 222051-59-4 2-[bis(pyrazol-1'-yl)methyl]-6-tert-butyl-4-methylphenol 
• 63551-07-5 N,N'-bis(2-hydroxy-3-tert-butyl-5-methylbenzyl)-1,2-diaminoethane 
• 156974-07-1 bis(μ-3-tert-butyl-5-methyl-2-oxobenzaldehyde)bis[cis-methyl(trimethylphosphine)nickel] 
• 1142409-70-8 2-(((2'-amino-[1,1'-binaphthalen]-2-yl)imino)methyl)-6-(tert-butyl)-4-methylphenol 
• 174912-77-7 6,6'-((1,1')-([1,1'-binaphthalene]-2,2'-diylbis(azanylylidene))bis(methanylylidene))bis(2-(tert-butyl)-4-methylphenol) 

Relevant academic research and scientific papers

A highly fluorescent tri-nuclear boron complex with large Stokes shifts based on tripodal Schiff base: synthesis and photophysical properties

Abstract: In this study, a new imine-based tripodal ligand and its difluoroboron complex were designed and synthesized. This trinuclear-boron complex was prepared for the first time and fully characterized by common spectroscopic techniques such as 1

Synthesis and structure-activity relationship studies of hydrazide-hydrazones as inhibitors of laccase from trametes versicolor

A series of hydrazide-hydrazones 1-3, the imine derivatives of hydrazides and aldehydes bearing benzene rings, were screened as inhibitors of laccase from Trametes versicolor. Laccase is a copper-containing enzyme which inhibition might prevent or reduce the activity of the plant pathogens that produce it in various biochemical processes. The kinetic and molecular modeling studies were performed and for selected compounds, the docking results were discussed. Seven 4-hydroxybenzhydrazide (4-HBAH) derivatives exhibited micromolar activity Ki = 24-674 μM with the predicted and desirable competitive type of inhibition. The structure-activity relationship (SAR) analysis revealed that a slim salicylic aldehyde framework had a pivotal role in stabilization of the molecules near the substrate docking site. Furthermore, the presence of phenyl and bulky tert-butyl substituents in position 3 in salicylic aldehyde fragment favored strong interaction with the substrate-binding pocket in laccase. Both 3- and 4-HBAH derivatives containing larger 3-tert-butyl-5-methyl- or 3,5-di-tert-butyl-2-hydroxy-benzylidene unit, did not bind to the active site of laccase and, interestingly, acted as non-competitive (Ki = 32.0 μM) or uncompetitive (Ki = 17.9 μM) inhibitors, respectively. From the easily available laccase inhibitors only sodium azide, harmful to environment and non-specific, was over 6 times more active than the above compounds.

Comparative evaluation of antioxidant activity of 2-alkyl-4-methylphenols and their 6-n-octylaminomethyl derivatives

A series of 2-alkyl-4-methyl-6-n-octylaminomethylphenols (where alkyl is methyl or tert-butyl group, or terpene substituent) was synthesized. A comparative evaluation of the antioxidant properties of the starting alkyl- and terpenylphenols and their Mannich bases was carried out using in vitro assays. Structural features providing high antioxidant activity of these compounds were revealed.

Hexahydroxy nitride oxide silicon heterocyclic compound and preparation method thereof

The invention discloses a hexahydroxy nitride oxide silicon heterocyclic compound and a preparation method thereof. The compound is shown as a formula (I); R1 is straight chain C1-C6 alkyls, C1-C5 alkyls with side chains or halogen-containing groups; R2 i

Development of Highly Active and Regioselective Catalysts for the Copolymerization of Epoxides with Cyclic Anhydrides: An Unanticipated Effect of Electronic Variation

Recent developments in polyester synthesis have established several systems based on zinc, chromium, cobalt, and aluminum catalysts for the ring-opening alternating copolymerization of epoxides with cyclic anhydrides. However, to date, regioselective proc

Highly Enantioselective Epoxidation of α,β-Unsaturated Ketones Catalyzed by Rare-Earth Amides [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 with Phenoxy-Functionalized Chiral Prolinols

A simple and efficient catalytic enantioselective epoxidation of α,β-unsaturated ketones has been successfully developed, which was catalyzed by rare-earth metal amides [(Me3Si)2N]3RE(μ-Cl)Li(THF)3 (RE = Yb (1), La (2), Sm (3), Y (4), Lu (5)) in the presence of phenoxy-functionalized chiral prolinols at room temperature using tert-butylhydroperoxide (TBHP) as the oxidant. The combination of an Yb-based amide 1 and a chiral proligand (S)-2,4-di-tert-butyl-6-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)phenol) performed very well, and both the yields and the enantiomeric excess of the chiral epoxides reached up to 99% and 99% ee. (Figure Presented).

Design of postmetallocene catalytic systems of arylimine type for olefin polymerization: XVI. Synthesis of (N-aryl)salicylaldimines containing pent-4-enyloxy group and their complexes with titanium(IV) dichloride

Reactions of p-(pent-4-enyloxy)aniline with salicylaldehyde containing versatile substituents in the positions 3 and 5 in an open system without solvent at 130°C afforded a series of (N-aryl)salicylaldimines, which with TiCl2(OPr-i)2 formed complexes of titanium(IV) dichloride L2TiCl2.

Facile one-pot transformation of phenols into o-cyanophenols

The treatment of phenols with paraformaldehyde in the presence of MgCl2 and Et3N in THF at 80 C, followed by reaction with molecular iodine and aq. ammonia at room temperature provided the corresponding o-cyanophenols in moderate to good yields. The present reaction is a one-pot transformation of phenols into o-cyanophenols using much less expensive reagents than are typically used; the reaction is free of both transition-metals and cyanide. The utility of this reaction was highlighted during our preparation of Febuxostat from p-bromophenol.

Platinum(II) complexes with tetradentate schiff bases as ligands: Synthesis, Characterization and detection of DNA interaction by differential pulse voltammetry

Five sterically hindered platinum(II) complexes with tetradentate schiff bases as ligands, [Pt(L)] (L= N,N'-bisalicylidene-1,2-ethylenediamine (L 1), N,N'-bisalicylidene-1,2-cyclohexanediamine (L2), N,N'-bis(5-hydroxylsalicylidene)-1,2-cyclohexanediamine (L3), N,N'-bisalicylidene-1,2-diphenylethylenediamine (L4) and N,N'-bis(3-tert-butyl-5-methyl-salicylidene)-1,2- diphenylethylenediamine (L5) ) have been synthesized and characterized by IR spectroscopy and elemental analysis. The sterical hindrance of antitumor drug candidates potentially makes them less susceptible to deactivation by sulphur containing proteins and helping to overcome resistance mechanisms. The interaction of these metal complexes with fish sperm single-stranded DNA (ssDNA) was studied electrochemically based on the oxidation signals of guanine and adenine. Differential pulse voltammetry was employed to monitor the DNA interaction in solution by using renewable pencil graphite electrode. The results indicate that ligands with different groups can strongly affect the interaction between [Pt(L)] complexes and ssDNA due to sterical hindrances and complex [Pt(L 1)] has the best interaction with DNA among the five complexes.

A general and convenient route to oxazolyl ligands

A diverse range of chiral and achiral oxazolyl ligands, which have many applications including catalysis and luminescent devices, are synthesized simply in three steps from readily available and inexpensive phenol and amino alcohol starting materials. The method can be applied to ligands with electron-donating/-withdrawing and sterically demanding/undemanding substituents, and can conveniently be scaled up to >25 g of product.