916767-00-5Relevant articles and documents
Practical synthesis of new chiral cis-phthalazinones with potential for high phosphodiesterase(PDE4) inhibitory activity
Van Dang, Tinh,Jin, Chung Kenn,Miyamoto, Motoyuki,Ikee, Yoshifumi,Masuda, Takashi,Sano, Shigeki,Shiro, Motoo,Nagao, Yoshimitsu
, p. 2133 - 2144 (2008/01/27)
New chiral cis-tetrahydrophthalazinones were synthesized directly from the corresponding chiral (4R)- and (4S)-isopropyl-1,3-thiazolidine-2-thione amides in one-pot reaction involving mild aminolysis with hydrazine monohydrate followed by intramolecular c